DNAJA3
DnaJ homolog subfamily A member 3, mitochondrial, also known as Tumorous imaginal disc 1 (TID1), is a protein that in humans is encoded by the DNAJA3 gene on chromosome 16. This protein belongs to the DNAJ/Hsp40 protein family, which is known for binding and activating Hsp70 chaperone proteins to perform protein folding, degradation, and complex assembly. As a mitochondrial protein, it is involved in maintaining membrane potential and mitochondrial DNA (mtDNA) integrity, as well as cellular processes such as cell movement, growth, and death. Furthermore, it is associated with a broad range of diseases, including neurodegenerative diseases, inflammatory diseases, and cancers.
Structure
As a member of the DNAJ/Hsp40 protein family, DNAJA3 contains a conserved DnaJ domain, which includes an HPD motif that interacts with Hsp70 to perform its cochaperone function. The DnaJ domain is composed of tetrahelical regions containing a tripeptide of histidine, proline and aspartic acid situated between two helices. In addition, this protein contains a glycine/phenylalanine (G/F) rich linker region and a central cysteine-rich region similar to a zinc finger repeat, both characteristic of type I DnaJ molecular chaperones. The mitochondrial targeting sequence at its N-terminal directs the localization of the protein to the mitochondrial matrix.
Podcasts:
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by Donnie J
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by Donnie J
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You Make Me Feel
by: Donnie J[Verse 1:]
I can't explain
Don't understand but everyday I think about you
Your the one and it's for real
There ain't no words it's just how I feel
Deep down inside and I can't hide the way you make me feel so high
[Chorus:]
And I cannot deny
You make me feel...
Like a kid in a candy store
You make feel...
Like I've never been here before
You make me feel...
Everyday is my birthday
You makin' feel this way
You make me feel...
Like I just won the lottery
You make me feel...
Like I'm chanin' my ensame
And I thought about
Never thought I'd feel this way
You make me feel
[Hook:]
I'm gunna come get you I can't get you outta my mind
I'm gunna come get you girl I gotta make you more mine
[Verse 2:]
I get butterflys everytime
I stare deep into those eyes
Maybe I'm helpless or I'm just selfish
Cause I want you all too myself
Oooh what I'll give to make you mine
There's nothing that I would not try
And that's the reason why
You make me feel...
[Chorus:]
Like a kid in a candy store
You make feel...
Like I've never been here before
You make me feel...
Everyday is my birthday
You makin' feel this way
You make me feel...
Like I just won the lottery
You make me feel...
Like I'm chanin' my ensame
And I thought about
Never thought I'd feel this way
You make me feel
[Verse 3:]
I'm gunna come get you I can't get you outta my mind
I can't help my hearts like and open book
Won't you take a look
Cause' it ain't hard to see that you got me
OH NA
Baby... the way you got me feelin' is kinda
Crazy... what you got is what I need
I'm lovin' everything I see
We fit perfectly
Cause...
[Chorus:]
You make me feel...
Like a kid in a candy (ohh)
You make me feel...
Like I've never been here before (mmm)
Everyday is my birthday
Everyday is my bithday (yeah) feel this way
I said you make me feel...
Like I just won the lottery (oh like I just won the lottery)
Like I'm changin my ensame
And... I thought about never thought I'd feel this way