DMP1
Dentin matrix acidic phosphoprotein 1 is a protein that in humans is encoded by the DMP1 gene.
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family (other members being DSPP, IBSP, MEPE, and SPP1). This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.
Podcasts:
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by Prince
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by The Crow soundtrack
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by Medicine
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by The Honeyz
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by Honeyz
Do Me Baby
by: PrinceHere we are in this big old empty room, staring each other down
U want me just as much as I want u, lets stop fooling around
Take me baby... kiss me all over... play with my love
Bring out what's been in me for far too long
Baby, u know that's all Ive been dreaming of
Do me baby, like u never done before
Give it to me till I just can't take no more
Do me baby, like u never done before
I want u now, I just can't wait no more, can't wait...
Here we are looking for a reason for u to lay me down
For a love like ours is never out of season, so baby please stop teasing me
What ya do, I can never love no other, ure the best I ever had
Whenever were not close to one another, I just want u so bad
So do me baby, like u never done before
Give it to me till I just can't take no more
Cmon, do me baby, like u never done before
I want u now, I just can't wait no more
I said ooo...ooo...oooo...ooooooo
Do me baby, do me baby, give it to me
Do me baby, I want u now
Do me baby, give it to me
Do me baby, do me baby, don't wanna do it all alone
I want your love.
Do me baby, give it to me
Do me baby, this feeling is too strong, make me wait 2 long, I want u now
Youre leaving me no choice
Ok, what are u gonna do...u just gonna sit there and watch? alright...
Are u sure u don't wanna close your eyes?
...well, isn't it supposed to take a long time?
Im not gonna stop till the war is over...
Help me! there...ok...ok