DKK3
Dickkopf-related protein 3 is a protein that in humans is encoded by the DKK3 gene.
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.
References
Further reading
DKK1
Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene.
Function
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the Wnt signaling pathway. Dickkopf WNT signaling pathway inhibitor 1 (Dkk1) is a protein-coding gene that acts from the anterior visceral endoderm. The dickkopf protein encoded by DKK1 is an antagonistic inhibitor of the WNT signaling pathway that acts by isolating the LRP6 co-receptor so that it cannot aid in activating the WNT signaling pathway. DKK1 was also demonstrated to antagonize the Wnt/β-catenin pathway via a reduction in β-catenin and an increase in OCT4 expression. This inhibition plays a key role in heart, head and forelimb development during anterior morphogenesis of the embryo.
Interactions
DKK1 has been shown to interact with LRP6.
Clinical significance
Elevated levels of DKK1 in bone marrow, plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
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by Take 5
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by Take 5
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by Taco
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Never Far Away
by: Take 5Everything I do Is all done for you
Lady I'm yours
And everywhere I go
You're always on my mind
You're all I adore
And I'll go
Outta my way
Just to assure
That our love endures I'm yours
Girl I'm never far away I'll be right there (right there)
To keep you nice and warm I'm rushing right home
Girl I'm never far away I'll be right there (right there)
To protect you from the storm I'm rushing right home
Girl I'll be there I'll be right there
I don't need you say
That I love you
A million times a day
Just the little things I do
All done for you
That's how I display
Love
And I'll go
Out of my way
Just to assure you baby
That our love endures I'm yours
Girl I'm never far away I'll be right there (right there)
To keep you nice and warm
(Girl I'll keep you nice and warm,
You know I'll keep you nice and warm
You know I'll keep you nice and warm)
Girl I'm never far away I'll be right there (I'll be right there)
To protect you from the storm I'm rushing right home
Girl I'll be there I'll be right there
You don't have to go and check my pager
Check my phone and search my pants to figure me out (ha)
Cause I'm an honest man
Don't need a plan, a stronger man
Cause girl there is no doubt
My love's real (as real as it comes)
Even though we are a million miles away from each other
I'm still right here, right here for you
(Here for you, here for you) I could search a million years
And still I wouldn't find anyone as beautiful as you
So rest assured our love endures I'm never far away...
(I'm rushing home baby, I'm coming home baby) I'm never far away...
(I'm rushing home baby, home baby, home baby) I'm never far away...
(I'm rushing home baby, I'm coming home baby) I'm never far away...
(I'm rushing home baby, home baby, home baby) I'm never far away...
(I'm rushing home baby, I'm coming home baby) I'm never far away...
(I'm rushing home baby, home baby, home baby) I'm never, never, never, never far Never, never, never, never far
Never far, never far I'm never far away I'm never far away...
(I'm rushing home baby, I'm coming home baby) I'm never far away...
(I'm rushing home baby, home baby, home baby) I'm never far away...
(I'm rushing home baby, I'm coming home baby) I'm never far away...
(I'm rushing home baby, home baby, home baby) I'm never far away...
(I'm rushing home baby, I'm coming home baby) I'm never far away...
(I'm rushing home baby, home baby, home baby) I'm never, never, never, never far Never, never, never, never far
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五一黄金周休假停业通知 (DKK-TOA Corporation)
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