3-Dehydroquinic acid
3-Dehydroquinic acid (DHQ) is the first carbocyclic intermediate of the shikimate pathway. It is created from 3-deoxyarabinoheptulosonate 7-phosphate, a 7-carbon ulonic acid, by the enzyme DHQ synthase. The mechanism of ring closure is complex, but involves an aldol condensation at C-2 and C-7.
It has the same structure as quinic acid, which is found in coffee, but the C-3 hydroxyl is oxidized to a ketone group. 3-Dehydroquinic acid undergoes five further enzymatic steps in the remainder of the shikimate pathway to chorismic acid, a precursor to tyrosine, 3-phenylalanine, tryptophan, and some vitamins, including:
3-Dehydroquinate can also be a precursor to pyrroloquinoline quinone (PQQ), an alternate redox coenzyme involved in oxidative phosphorylation.
Biosynthesis
3-Dehydroquinate goes through beta oxidation, similar to fatty acids. Then, this compound (6-oxo-3-dehydro-quinate) is transaminated to 6-amino-3-dehydroquinate. Then 6-amino-3-dehydro-quinate is dehydrated and reduced to 6-amino-4-desoxy-3-keto-quinate, which reacts with dehydroalanine and alpha-ketoglutarate, to form hexahydro-pyrroloquinoline quinone. This compound is oxidized by FAD to PQQ.
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Never Far Away
by: Take 5Everything I do Is all done for you
Lady I'm yours
And everywhere I go
You're always on my mind
You're all I adore
And I'll go
Outta my way
Just to assure
That our love endures I'm yours
Girl I'm never far away I'll be right there (right there)
To keep you nice and warm I'm rushing right home
Girl I'm never far away I'll be right there (right there)
To protect you from the storm I'm rushing right home
Girl I'll be there I'll be right there
I don't need you say
That I love you
A million times a day
Just the little things I do
All done for you
That's how I display
Love
And I'll go
Out of my way
Just to assure you baby
That our love endures I'm yours
Girl I'm never far away I'll be right there (right there)
To keep you nice and warm
(Girl I'll keep you nice and warm,
You know I'll keep you nice and warm
You know I'll keep you nice and warm)
Girl I'm never far away I'll be right there (I'll be right there)
To protect you from the storm I'm rushing right home
Girl I'll be there I'll be right there
You don't have to go and check my pager
Check my phone and search my pants to figure me out (ha)
Cause I'm an honest man
Don't need a plan, a stronger man
Cause girl there is no doubt
My love's real (as real as it comes)
Even though we are a million miles away from each other
I'm still right here, right here for you
(Here for you, here for you) I could search a million years
And still I wouldn't find anyone as beautiful as you
So rest assured our love endures I'm never far away...
(I'm rushing home baby, I'm coming home baby) I'm never far away...
(I'm rushing home baby, home baby, home baby) I'm never far away...
(I'm rushing home baby, I'm coming home baby) I'm never far away...
(I'm rushing home baby, home baby, home baby) I'm never far away...
(I'm rushing home baby, I'm coming home baby) I'm never far away...
(I'm rushing home baby, home baby, home baby) I'm never, never, never, never far Never, never, never, never far
Never far, never far I'm never far away I'm never far away...
(I'm rushing home baby, I'm coming home baby) I'm never far away...
(I'm rushing home baby, home baby, home baby) I'm never far away...
(I'm rushing home baby, I'm coming home baby) I'm never far away...
(I'm rushing home baby, home baby, home baby) I'm never far away...
(I'm rushing home baby, I'm coming home baby) I'm never far away...
(I'm rushing home baby, home baby, home baby) I'm never, never, never, never far Never, never, never, never far
Latest News for: dhq
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