Dhap
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Dihydroxyacetone phosphate

Dihydroxyacetone phosphate (DHAP, also glycerone phosphate in older texts) is a biochemical compound involved in many metabolic pathways, including the Calvin cycle in plants and glycolysis.

Role in glycolysis

Dihydroxyacetone phosphate lies in the glycolysis metabolic pathway, and is one of the two products of breakdown of fructose 1,6-bisphosphate, along with glyceraldehyde 3-phosphate. It is rapidly and reversibly isomerised to glyceraldehyde 3-phosphate.

Compound C05378 at KEGG Pathway Database. Enzyme 4.1.2.13 at KEGG Pathway Database. Compound C00111 at KEGG Pathway Database. Compound C00118 at KEGG Pathway Database.

The numbering of the carbon atoms indicates the fate of the carbons according to their position in fructose 6-phosphate.

Compound C00111 at KEGG Pathway Database.Enzyme 5.3.1.1 at KEGG Pathway Database.Compound C00118 at KEGG Pathway Database.

Click on genes, proteins and metabolites below to link to respective articles.

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DHAP (chemotherapy)

DHAP in context of chemotherapy is an acronym for chemotherapy regimen that is used for remission induction in cases of relapsed or refractory Non-Hodgkin lymphoma and Hodgkin disease. It is usually given for 2-3 courses, then followed by high-dose chemotherapy and autologous stem cell transplant. In combination with anti-CD20 monoclonal antibody Rituximab (Rituxan, Mabthera) it is called R-DHAP or DHAP-R.

[R]-DHAP regimen consists of:

  • Rituximab, a monoclonal antibody, directed at B-cell surface antigen CD20
  • (D)examethasone, a glucocorticoid hormone
  • (H)igh-dose (A)ra-C - cytarabine, an antimetabolite;
  • (P)latinol (cisplatin), a platinum-based antineoplastic agent with an alkylating mechanism;
  • Dosing regimen

    References

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