DFFB

DNA fragmentation factor subunit beta is a protein that in humans is encoded by the DFFB gene.

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.

Interactions

DFFB has been shown to interact with DFFA.

Deutscher Fernsehfunk

Deutscher Fernsehfunk (DFF), known from 1972 to 1990 as Fernsehen der DDR (DDR-FS), was the state television broadcaster in East Germany.

History

Foundation

Radio was the dominant medium in the former Eastern bloc, with television being considered low on the priority list when compiling Five-Year Plans during the industrialisation of the 1950s. In Germany, the situation was different as East and West Germany were in competition over available frequencies for broadcasts and for viewers across the Iron Curtain. The West German Nordwestdeutscher Rundfunk (NWDR) had made early plans to begin television broadcasts in its area, which originally included West Berlin. The first western test broadcasts were made in 1950.

The GDR authorities therefore also made an early start with television and began construction of a television centre in Adlershof on 11 June 1950. The GDR television service began experimental test broadcasts on 20 December 1951. The NWDR announced plans to begin a regular television service from Hamburg starting with Christmas 1952. This spurred the East German authorities into further action.

DFF

DFF may refer to:

In organisations

Other uses