Department

Department may refer to:

  • Departmentalization, division of a larger organization into parts with specific responsibility
  • Government and military

  • Department (country subdivision), a geographical and administrative division within a country
  • Departments of Colombia, a grouping of municipalities
  • Departments of France, administrative divisions three levels below the national government
  • Departments of Honduras
  • Departments of Peru, name given to the subdivisions of Peru until 2002
  • Department (United States Army), corps areas of the U.S. Army prior to World War I
  • Fire department, a public or private organization that provides emergency firefighting and rescue services
  • Ministry (government department), a specialized division of a government
  • Police department, a body empowered by the state to enforce the law
  • DEPT (medicine)

    Directed Enzyme Prodrug Therapy (DEPT) uses enzymes artificially introduced into the body to convert Prodrugs, which have no or poor biological activity, to the active form in the desired location within the body. Many chemotherapy drugs for cancer lack tumour specificity and the doses required to reach therapeutic levels in the tumour are often toxic to other tissues. DEPT strategies are an experimental method of reducing the systemic toxicity of a drug, by achieving high levels of the active drug only at the desired site. This article describes the variations of DEPT technology.

    Antibody-directed enzyme prodrug therapy (ADEPT)

    ADEPT is a strategy to overcome the problems of lack of tumor selectivity. An antibody designed/developed against a tumor antigen is linked to an enzyme and injected to the blood, resulting in selective binding of the enzyme in the tumor. When the discrimination between tumor and normal tissue enzyme levels is sufficient, a prodrug is administrated into the blood circulation, which is converted to an active cytotoxic drug by the enzyme, only within the tumor. Selectivity is achieved by the tumor specificity of the antibody and by delaying prodrug administration until there is a large differential between tumor and normal tissue enzyme levels.

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    Draft proposes reshaping of State Dept.

    Tyler Morning Telegraph 21 Apr 2025
    A draft Trump administration executive order circulating among U.S. diplomats proposes a radical reduction to and restructuring of the State Department, according to a copy of the document seen by Bloomberg ....
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    Delhi Transport Dept To Fine Vehicles Without Colour-Coded Fuel Stickers

    News18 21 Apr 2025
    The Motor Vehicles (High Security Registration Plates) Order, 2018 makes it compulsory to display colour-coded stickers (called the third registration mark) on the windshield ... .
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    Warring flays Punjab tax dept’s ‘arm-twisting’ tactics

    Hindustan Times 21 Apr 2025
    Punjab Congress president Amarinder Singh Raja Warring (HT File) ... Warring added that the ETOs were asked to collect at least ₹8 lakhs from each raid ... News / Cities / Chandigarh / Warring flays Punjab tax dept’s ‘arm-twisting’ tactics. See Less ....
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    Ludhiana: Edu dept issues strict orders on school project completion

    Hindustan Times 21 Apr 2025
    Clear directives have been issued to ensure that no unfinished work is presented as complete during upcoming events under the ‘Sikhya Kranti’ campaign ... (HT File) ... Edu dept issues strict orders on school project completion. See Less ....
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    Trump Justice Dept. weighs trying to undo Peter Navarro’s conviction

    The Washington Post 20 Apr 2025
    Two days after announcing tariff hikes championed by Navarro, the Trump administration said it may drop opposition to the White House trade adviser’s appeal ... .
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