DDB2

DNA damage-binding protein 2 is a protein that in humans is encoded by the DDB2 gene.

Function

DDB2 is the smaller subunit of a heterodimeric protein implicated in the etiology of xeroderma pigmentosum group E. This subunit appears to be required for DNA binding.

Interactions

DDB2 has been shown to interact with CUL4A,CUL4B and DDB1. Also, some researches about DDB2 show a relationship between DDB2 and PARP1.PARP1 as a novel DDB2-associated factor,which may help to recruitment a chromatin-remodeling enzyme,named ALC1.

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Further reading

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