DDB1
DNA damage-binding protein 1 is a protein that in humans is encoded by the DDB1 gene.
Function
This gene encodes the large subunit of DNA damage-binding protein that is a heterodimer composed of a large and a small (DDB2) subunit. As its name suggests, DDB1 was initially implicated in the process of a specific type of DNA repair known as nucleotide excision repair. Since then, researchers have found that DDB1 primarily functions as a core component of the CUL4A- and CUL4B-based E3 ubiquitin ligase complexes. DDB1 serves as a bridge or adaptor protein which interacts with dozens of proteins known as DDB1 and CUL4-associated factors (DCAFs). These DCAFs are often ubiquitin ligase substrates and regulate numerous essential processes in the cell including DNA repair (DDB2), DNA replication, chromatin remodeling (Cdt2) and more.
Interactions
DDB1 has been shown to interact with Transcription initiation protein SPT3 homolog,GCN5L2,DDB2,CUL4A,CUL4B and P21.
References
Further reading
Podcasts:
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by Toby Beau
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by Dope Boy
My Angel Baby
by: Toby BeauWe've got trouble
something's just not right
Just this mornin' you
cried about last night
You said that somethin's
bound to break this time
What's breakin' is my heart
I can read between the lines
It's tearin' me apart
you've got leavin' on your mind
(chorus)
But you're my angel baby
Yes you're my angel baby
Woh you're my angel baby
for the rest of the night
Do you remember
how it used to be?
Lovin' was easier
when you were lovin' me
I guess you found
someone and now I find
What's breakin' is my heart
You've got leavin' on your mind
(chorus)
What's breakin' is my heart
I can read between the lines
It's tearin' me apart
you've got leavin' on your mind
(chorus)
For the rest of the night
(Angel Baby) the rest of the night
(Angel Baby, Angel Baby)
the rest of the night
(Angel Baby) the rest of the night
(Angel Baby) the rest of the night