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| Death-associated protein | |||
|---|---|---|---|
| Identifiers | |||
| Symbols | DAP; MGC99796 | ||
| External IDs | OMIM: 600954 MGI: 1918190 HomoloGene: 3235 GeneCards: DAP Gene | ||
| RNA expression pattern | |||
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| More reference expression data | |||
| Orthologs | |||
| Species | Human | Mouse | |
| Entrez | 1611 | 223453 | |
| Ensembl | ENSG00000112977 | ENSMUSG00000039168 | |
| UniProt | P51397 | Q91XC8 | |
| RefSeq (mRNA) | NM_004394.2 | NM_146057.3 | |
| RefSeq (protein) | NP_004385.1 | NP_666169.1 | |
| Location (UCSC) | Chr 5: 10.68 – 10.76 Mb |
Chr 15: 31.15 – 31.2 Mb |
|
| PubMed search | [1] | [2] | |
Death-associated protein 1 is a protein that in humans is encoded by the DAP gene.[1][2][3]
DAP gene encodes a basic, proline-rich, 15-kD protein. Death-associated protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma.[3]
References [link]
- ^ Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K (Feb 1996). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively". Genomics 29 (1): 305–7. DOI:10.1006/geno.1995.1255. PMID 8530096.
- ^ Deiss LP, Feinstein E, Berissi H, Cohen O, Kimchi A (Feb 1995). "Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death". Genes Dev 9 (1): 15–30. DOI:10.1101/gad.9.1.15. PMID 7828849.
- ^ a b "Entrez Gene: DAP death-associated protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1611.
Further reading [link]
- Levy-Strumpf N, Kimchi A (1999). "Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions". Oncogene 17 (25): 3331–40. DOI:10.1038/sj.onc.1202588. PMID 9916995.
- Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. DOI:10.1016/j.cell.2006.09.026. PMID 17081983.
- Zougman A, Wiśniewski JR (2006). "Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins". J. Proteome Res. 5 (4): 925–34. DOI:10.1021/pr050415p. PMID 16602700.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Suzuki Y, Yamashita R, Shirota M et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. DOI:10.1101/gr.2435604. PMC 515316. PMID 15342556. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515316.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
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DAP
Dap or DAP may refer to:
Science
Computers
Early education
Groups
Giving dap
Dap is a friendly gesture of greeting, agreement, or solidarity between two people that has become popular in western cultures, particularly since the 1970s, originating from African American communities. Giving dap typically involves handshaking (often, by hooking thumbs), pound hugging, fist pounding, or chest- or fist bumping. The practice and term originated among black soldiers during the Vietnam War, as part of the Black Power movement, and the term is attested since 1971.
Giving dap can refer to presenting many kinds of positive nonverbal communication between two people, ranging from a brief moment of simple bodily contact to a complicated routine of hand slaps, shakes, snaps, etc. known only by the two participants. Elaborate examples of dap are observed as a pregame ritual performed by many teams in the National Basketball Association. These choreographed actions are rarely televised and serve as a superstitious means of psychological preparation and team solidarity.
Daf
The daf (Persian: دف, from Middle Persian: dap) is a large Persian frame drum used in popular and classical music. The frame is usually made of hardwood with many metal ringlets attached, and the membrane is usually goatskin. Daf is mostly used in the Middle East, Kurdistan, Azerbaijan, Iran, Armenia, Turkey, Pakistan, Afghanistan and Central Asia, and usually accompanies singers and players of the tanbur, violin, oud, saz and other Middle Eastern instruments. Some dafs are equipped with small cymbals, making them analogous to a large tambourine.
History
The earliest evidence of the Dap (Daf) dates back to Sassanid Iran. The Pahlavi (an ancient Iranian language) name of the daf is dap. The word daf is therefore the Arabicized form of the word dap. Some pictures of dap have been found in paintings that date before the Common Era. The presence of Iranian dap in the reliefs of Behistun suggests the daf existed before the rise of Islam. Dafs were part of religious music in Iran much before Sufism. Iranian music has always been a spiritual tool. It shows that dafs played an important role in Mazdean Iran emerging as an important element during the Sassanian times during the Kâvusakân dynasty. Also there is a kind of square frame drum in the stonecutting of Taq-e Bostan (another famous monument located 5 km (3 mi) northeast of Kermanshah city). These frame drums were played in the ancient Middle East (chiefly by women in Kurdish societies), Greece, and Rome and reached medieval Europe through Islamic culture.
Gene
A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.
Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term "having a gene" (e.g., "good genes," "hair colour gene") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.
Eugene (given name)
Eugene is a common (masculine) first name that comes from the Greek εὐγενής (eugenēs), "noble", literally "well-born", from εὖ (eu), "well" and γένος (genos), "race, stock, kin".Gene is a common shortened form. The feminine variant is Eugenia or Eugénie.
Male foreign-language variants include:
Notable people
Christianity
Military
Gene (novel)
Gene is a thriller novel by Stel Pavlou (born 1970), published in 2005 in England by Simon & Schuster. It is published in several languages with some title changes. The Italian edition has the title La Conspirazione del Minotauro (The Minotaur Conspiracy). The novel is about a fictional New York detective, James North, who in the process of hunting down a criminal, uncovers a genetics experiment to unlock past lives through genetic memory, therefore achieving a kind of immortality. In so doing North discovers his own origins, that of a soldier from the Trojan War who is reincarnated seven times through history, forced to confront his nemesis each time, all for the loss of his one true love.
Characters
Cyclades (born circa 1300 BC)
Incarnations of Cyclades
Athanatos (born circa 1500 BC)
Incarnations of Athanatos
