Cyr wheel

The Cyr wheel (also known as the roue Cyr, mono wheel, or simple wheel) is an acrobatic apparatus that consists of a single large ring made of aluminum or steel with a diameter approximately 10 to 15 cm (4 to 6 in) taller than the performer. The performer stands inside the Cyr wheel and grasps its rim, causing it to roll and spin gyroscopically while performing acrobatic moves in and around the rotating wheel. The apparatus and its movement vocabulary have some similarities with the German wheel, but whereas the German wheel consists of two large rings linked together by horizontal crossbars and has handles for the performer to hold onto, the modern Cyr wheel consists of a single ring and has no handles. The Cyr wheel takes its name from Daniel Cyr, who reinvented it as a circus apparatus at the end of the 20th century.

There are records of people using a similar apparatus as sports equipment during the mid-20th century in Germany, where it was referred to as the Einreifen or mono wheel, having been developed by Adalbert von Rekowski as a variation on Otto Feick's popular Rhönrad (German wheel).

Cyr

Cyr is the name of several people:

Cyr is also the name of a place in the United States:

Cyr may also refer to:

CYR61

Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded by the CYR61 gene.

CYR61 is a secreted, extracellular matrix (ECM)-associated signaling protein of the CCN family (CCN intercellular signaling protein). CYR61 is capable of regulating a broad range of cellular activities, including cell adhesion, migration, proliferation, differentiation, apoptosis, and senescence through interaction with cell surface integrin receptors and heparan sulfate proteoglycans. During embryonic development, CYR61 is critical for cardiac septal morphogenesis, blood vessel formation in placenta, and vascular integrity. In adulthood CYR61 plays important roles in inflammation and tissue repair, and is associated with diseases related to chronic inflammation, including rheumatoid arthritis, atherosclerosis, diabetes-related nephropathy and retinopathy, and many different forms of cancers.

CCN protein family

CYR61 was first identified as a protein encoded by a serum-inducible gene in mouse fibroblasts. Other highly conserved homologs were later identified to comprise the CCN protein family (CCN intercellular signaling protein). The CCN acronym is derived from the first three members of the family identified, namely CYR61 (CCN1), CTGF (connective tissue growth factor, or CCN2), and NOV (nephroblastoma overexpressed, or CCN3). These proteins, together with WISP1 (CCN4), WISP2 (CCN5), and WISP3 (CCN6) comprise the six members of the family in vertebrates and have been renamed CCN1-6 in order of their discovery by international consensus. CCN proteins function as matricellular proteins, which are extracellular matrix proteins that play regulatory roles, particularly in the context of wound repair.

MIN-101

MIN-101 (former developmental code names CYR-101, MT-210) is a 5-HT_2A and σ₂ receptor antagonist that is under development by Minerva Neurosciences for the treatment of schizophrenia. One of its metabolites also has some affinity for the H₁ receptor. As of August 2015, the drug is in phase II clinical trials.

See also

References