Droop-E is a member of the production team The Pharmaceuticals and the son of Bay Area rapper E-40. He often works with his cousin B-Slimm.
Droop-E was born into a rapping family with his father E-40, his cousins B-Legit and Turf Talk, and with his uncle D-Shot and aunt Suga-T. His first record appearance came at age 5 when he was featured in "Questions" on E-40's Federal album. He also rapped on the track "It's All Bad" from E-40's 1995 album In a Major Way (credited as Lil E), mimicking his father's style. His production debut was at the age of 15 for the Turf Talk song "In The Heart Of The Ghetto" on Mack 10's 2003 compilation, Ghetto, Gutter & Gangster.