Ago

Ago or AGO may refer to:

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Argonaute

The Argonaute protein family plays a central role in RNA silencing processes, as essential catalytic components of the RNA-induced silencing complex (RISC). RISC complex is responsible for the gene silencing phenomenon known as RNA interference (RNAi). Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). Small RNAs guide Argonaute proteins to their specific targets through sequence complementarity (base pairing), which then leads to mRNA cleavage or translation inhibition.

Discovery

The RNA interference (RNAi) was first reported in 1995 by Guo and Kemphues, and similar pathways collectively referred to as RNA silencing were discovered in plants and fungi. The beginning of people’s understanding of the mechanism of RNA silencing began only in 1998 with the experiments of Fire and colleagues demonstrating that double-stranded RNA triggered RNAi. RNA silencing pathways process long RNAs into small RNAs that direct the repression of transcription or translation of nucleic acid targets with sequence corresponding to the small RNAs. These single-stranded RNAs, referred to as guide strands, are incorporated into RNA silencing effectors complexes such as the RNA-induced silencing complex (RISC). These RNA silencing effector complexes contain Argonaute family proteins.

Cruising

Cruising may refer to:

See also

Cruising (film)

Cruising is a 1980 American psychological thriller film written and directed by William Friedkin and starring Al Pacino. The film is loosely based on the novel of the same name, by The New York Times reporter Gerald Walker, about a serial killer targeting gay men, in particular those associated with the leather scene.

Poorly reviewed by critics, Cruising was a modest financial success, though the filming and promotion were dogged by gay rights protesters. The title is a play on words with a dual meaning, as "cruising" can describe police officers on patrol and also cruising for sex. The film is also notable for its open-ended finale, further complicated by the director's incoherent changes in the rough cut and synopsis, as well as due to other production issues.

Plot

In New York City during the middle of a hot summer, body parts of men are showing up in the Hudson River. The police suspect it to be the work of a serial killer who is picking up homosexual men at West Village bars like the Eagle's Nest, the Ramrod, and the Cock Pit, then taking them to cheap rooming houses or motels, tying them up and stabbing them to death.

Cruising (driving)

Cruising is a social activity that primarily consists of driving a car. Cruising can be an expression of the freedom of possessing a driver's license. Cruising is distinguished from regular driving by the social and recreational nature of the activity, which is characterized by an impulsively random, often aimless course. A popular route (or "strip") is often the focus of cruising. "Cruise nights" are evenings during which cars drive slowly, bumper-to-bumper, through small towns. Another common form is a "Booze Cruise": this is where a group of people go out 'cruising' and drinking. A cruise can be a meeting of car enthusiasts at a predetermined location, organised predominantly through the internet (in recent times) but also largely through mobile phone, word of mouth or simply by a cruise being established enough that it becomes a regular event.

United States

One of the oldest cruising strips is located on Whittier Boulevard in East Los Angeles. Cruising on this strip became a popular pastime with the lowriding community during the 1940s before spreading to surrounding neighborhoods in the 1950s.Van Nuys Boulevard in the central San Fernando Valley has been a popular cruising strip since the 1950s-1960s; the 1979 film Van Nuys Blvd. depicted the cruising culture on the strip. Perhaps the most famous cruising strip (or main drag), however, is McHenry Avenue in Modesto, California. The cruising culture of the late 1950s and early 1960s was depicted in the film American Graffiti. The film was set (but not actually filmed) in director George Lucas's home town of Modesto, which also hosts an annual "Graffiti Summer" celebration in the film's honor.