Newline

In computing, a newline, also known as a line ending, end of line (EOL), or line break, is a special character or sequence of characters signifying the end of a line of text and the start of a new line. The actual codes representing a newline vary across operating systems, which can be a problem when exchanging text files between systems with different newline representations.

The concepts of line feed (LF) and carriage return (CR) are closely associated, and can be either considered separately or lumped together. In the physical media of typewriters and printers, two axes of motion, "down" and "across", are needed to create a new line on the page. Although the design of a machine (typewriter or printer) must consider them separately, the abstract logic of software can lump them together as one event. This is why a newline in character encoding can be defined as LF and CR combined into one (CR+LF, CRLF, LF+CR, LFCR).

Two ways to view newlines, both of which are self-consistent, are that newlines separate lines or that they terminate lines. If a newline is considered a separator, there will be no newline after the last line of a file. Some programs have problems processing the last line of a file if it is not terminated by a newline. On the other hand, programs that expect newline to be used as a separator will interpret a final newline as starting a new (empty) line.

CRLF1

Cytokine receptor-like factor 1 is a protein that in humans is encoded by the CRLF1 gene.

Function

This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells.

Clinical significance

Mutations in this gene are associated with two conditions, both rare:

It is unknown whether the two conditions are distinct clinical entities or a single clinical entity with variable expressions. Other characteristic features in CRLF1 mutation include marfanoid habitus with progressive kyphoscoliosis and craniofacial characteristics including dolichocephaly, a slender face with poor expression, a nose with hypoplastic nares, malar hypoplasia and prognathism.

CRLF2

Cytokine receptor-like factor 2 is a protein that in humans is encoded by the CRLF2 gene.

Cytokine signals are mediated through specific receptor complexes, the components of which are mostly members of the type I cytokine receptor family. Type I cytokine receptors share conserved structural features in their extracellular domain. Receptor complexes are typically heterodimeric, consisting of alpha chains, which provide ligand specificity, and beta (or gamma) chains, which are required for the formation of high-affinity binding sites and signal transduction.[supplied by OMIM]

References

Further reading