Crion

Crion is a commune in the Meurthe-et-Moselle department in north-eastern France.

See also

Chronic relapsing inflammatory optic neuropathy

Chronic relapsing inflammatory optic neuropathy (CRION), sometimes called chronic relapsing inflammatory optic neuritis, is a form of recurrent optic neuritis that is steroid responsive. Patients typically present with pain associated with visual loss. CRION is a diagnosis of exclusion, and other demyelinating, autoimmune, and systemic causes should be ruled out. Early recognition is crucial given risks for severe visual loss and because it is treatable with immunosuppressive treatment such as steroids. Relapse that occurs after reducing or stopping steroids is a characteristic feature

Pathogenesis

The etiology remains unknown. Given that CRION is responsive to immunosuppressive treatment, it may be immune-mediated. CRION has been classified as an autoimmune process but this description is not established with certainty and there is no known associated autoimmune antibody

Signs and Symptoms

Pain, visual loss, relapse, and steroid response are typical of CRION. Ocular pain is typical, although there are some cases with no reported pain. Bilateral severe visual loss (simultaneous or sequential) usually occurs, but there are reports of unilateral visual loss. Patients can have an associated relative afferent pupillary defect. CRION is associated with at least one relapse, and up to 18 relapses have been reported in an individual. Interval between episodes can range from days to over a decade. Symptoms will improve with corticosteroids, and recurrence characteristically occurs after reducing or stopping steroids.