Pycard

Pycard, also spelt Picard and Picart (late 14th century – early 15th century) was an English or French Medieval and Renaissance transitional composer.

He may have served in John of Gaunt's household in the 1390s as 'Jehan Pycard alias Vaux'. The name "Picard" suggests a French origin, but his music is regarded as being in an English tradition. He is one of the most prolific composers represented in the Old Hall Manuscript (British Library: Additional 57950), with nine works from it attributed to him. His music is in the ars nova style, and is unusual in its virtuosity.

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PYCARD

Apoptosis-associated speck-like protein containing a CARD or ASC is a protein that in humans is encoded by the PYCARD gene.

Function

This gene encodes an adaptor protein that is composed of two protein–protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.

Interactions

PYCARD has been shown to interact with MEFV.

References

Further reading