PTGS1

Cyclooxygenase-1 (COX-1), also known as prostaglandin G/H synthase 1, prostaglandin-endoperoxide synthase 1 or prostaglandin H2 synthase 1, is an enzyme that in humans is encoded by the PTGS1 gene.

History

Cyclooxygenase (COX) is the central enzyme in the biosynthetic pathway to prostaglandins from arachidonic acid. This protein was purified more than 20 years ago and cloned in 1988.

Gene and isozymes

There are two isozymes of COX encoded by distinct gene products: a constitutive COX-1 (this enzyme) and an inducible COX-2, which differ in their regulation of expression and tissue distribution. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. A splice variant of COX-1 termed COX-3 was identified in the CNS of dogs, but does not result in a functional protein in humans. Two smaller COX-1-derived proteins (the partial COX-1 proteins PCOX-1A and PCOX-1B) have also been discovered, but their precise roles are yet to be described.

Cox

Cox may refer to:

Companies

Places

Science and technology

See also

Cox (surname)

The surname Cox is of English or Welsh origin, and may have originated independently in several places in Great Britain, with the variations arriving at a standard spelling only later. There are also two native Irish surnames which were anglicised into Cox.

An early record of the surname dates from 1556 with the marriage of Alicea Cox at St. Martin in the Fields, Westminster, London. Cox is the 69th-most common surname in the United Kingdom.

Origin

One possibility of the origin is that it is a version of the Old English cocc which means "the little", and was sometimes put after the name of a leader or chieftain as a term of endearment. Surnames such as Wilcox, Willcocks and Willcox are examples of this practice: all are composed of the name William and the archaic word cocc, coming together to mean "little William". The suggestion is that only the element -cox may have endured as a surname for some families.

Another opinion is that the name is derived from the Old English cock, which means a "heap" or "mound", and was a topographic name for a man living near any heap, hill or other bundle. Names like Haycock or Haycox come from such practice, meaning from "the hay mounds" or "the hay fields". Again, the element -cox may have only been carried on in some families.

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