Cowden syndrome

Cowden syndrome (also known as "Cowden's disease," and "Multiple hamartoma syndrome") is a rare autosomal dominant inherited disorder characterized by multiple non-cancerous tumor-like growths called hamartomas, which typically are found in the skin, mucous membranes (mouth, nasal membranes, GI tract), thyroid gland, and breast tissue. While the hamartomas are benign, people with Cowden Syndrome are at increased risk of certain forms of cancer, including breast, thyroid, uterus (endometrial), and kidney cancers.

Cowden syndrome is associated with mutations in PTEN, a tumor suppressor gene, that cause the PTEN protein not to work properly leading to hyperactivity of the mTOR pathway. These mutations lead to characteristic features including macrocephaly, intestinal hamartomatous polyps, benign skin tumors (multiple trichilemmomas, papillomatous papules, and acral keratoses) and dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease). In addition, there is a predisposition to breast carcinoma, follicular carcinoma of the thyroid, and endometrial carcinoma.

Cowden

Coordinates: 51°08′41″N 0°05′36″E / 51.144765°N 0.093459°E / 51.144765; 0.093459

Cowden (/kaʊˈdɛn/) is a small village and civil parish in the Sevenoaks District of Kent, England. The parish is located on the northern slopes of the Weald, south-west of Tonbridge. The old High Street has Grade II listed cottages and village houses, and there is an inn called The Fountain.

History

The Romans built the London to Lewes Way across what is now the garden of Waystrode Manor. The first owners of the manor received it from King John in 1208.

Crippenden Manor, built in about 1607, was once the home of ironmaster, Richard Tichborne (1568-1639), related to the Tichbornes of Tichborne, Hampshire. This branch of the Tichbornes descended from a younger son of John Tichborne and Margaret Martin, who inherited his mother's lands in and around Edenbridge, including Crippenden. Richard was the son of John Tichborne (c1549-1620) and Dorothy Chaloner, daughter of Thomas Chaloner of Lyndfield and his wife, Alice Shirley. Richard married Dorothy Saxbie, circa 1592, and had at least ten children, including Dorothy who married John Tillinghast (1604–55), son of the Rector of Streat, who was also involved in the iron industry. Richard formally leased Crippenden from 1612 and built the house there. It descended to Captain Edmund Tichborne who sold the manor after 1721.

Cowden (disambiguation)

Cowden is a small village and civil parish in the Sevenoaks District of Kent, England.

Cowden may also refer to:

People with the given name Cowden:

People with the surname Cowden:

See also