DMT
DMT may refer to the following:
Chemical substances
Sports
Other uses
2,alpha-DMT
2,alpha-DMT, or 2,α-dimethyltryptamine, is a tryptamine and a lesser-known psychedelic drug. It is the 2,a-dimethyl analog of DMT. 2,α-DMT was first synthesized by Alexander Shulgin. In his book TiHKAL (Tryptamines I Have Known and Loved), Shulgin lists the dosage as 300-500 mg, and the duration as 7-10 hours. 2,α-DMT causes mydriasis and paresthesia. It also produces a calm, drunk-like feeling. Very little data exists about the pharmacological properties, metabolism, and toxicity of 2,α-DMT.
References
External links
DMT1
The divalent metal transporter 1 (DMT1), also known as natural resistance-associated macrophage protein 2 (NRAMP 2), and divalent cation transporter 1 (DCT1), is a protein that in humans is encoded by the SLC11A2 (solute carrier family 11, member 2) gene. DMT1 represents a large family of orthologous metal ion transporter proteins that are highly conserved from bacteria to humans.
As its name suggests, DMT1 binds a variety of divalent metals including cadmium (Cd2+), copper (Cu2+), and zinc (Zn2+,,) however it is best known for its role in transporting ferrous iron (Fe2+); DMT1 expression is regulated by body iron stores to maintain iron homeostasis. DMT1 is also important in the absorption and transport of manganese (Mn2+). In the digestive tract, it is located on the apical membrane of enterocytes, where it carries out H+ coupled transport of divalent metal cations from the intestinal lumen into the cell.
Role in neurodegenerative diseases
Toxic accumulation of divalent metals, especially iron and/or manganese, are frequently discussed aetiological factors in a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. DMT1 may be the major transporter of manganese across the blood brain barrier and expression of this protein in the nasal epithelium provides a route for direct absorption of metals into the brain. DMT1 expression in the brain may increase with age, increasing susceptibility to metal induced pathologies. DMT1 expression is found to be increased in the substantia nigra of Parkinson's patients and in the ventral mesencephalon of animal models intoxicated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) - a neurotoxin widely used experimentally to produce Parkinsonian symptoms.
GETS
GETS or Gets may refer to:
Getae
The Getae /ˈdʒiːtiː/ or /ˈɡiːtiː/ or Gets (Ancient Greek: Γέται, singular Γέτης; Bulgarian: Гети; Romanian: Geţi) are names given to several Thracian tribes inhabiting the regions to either side of the Lower Danube, in what is today northern Bulgaria and southern Romania. Both the singular form Get and Getae may be derived from a Greek exonym: the area was the hinterland of Greek colonies on the Black Sea coast, bringing the Getae into contact with the Ancient Greeks from an early date.
Getae and Dacians
Ancient sources
Strabo, one of the first ancient sources to mention Getae and Dacians, stated in his Geographica (ca. 7 BC – 20 AD) that the Dacians lived in the western parts of Dacia, "towards Germania and the sources of the Danube", while Getae in the eastern parts, towards the Black Sea, both south and north of the Danube. The ancient geographer also wrote that the Dacians and Getae spoke the same language, after stating the same about Getae and Thracians.
Pliny the Elder, in his Naturalis Historia (Natural History), ca. 77–79 AD, states something similar: "... though various races have occupied the adjacent shores; at one spot the Getae, by the Romans called Daci...".
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