MRE11A

Double-strand break repair protein MRE11A is a protein that in humans is encoded by the MRE11A gene.

Function

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Orthologs of MRE11A

Mre11, an ortholog of human MRE11A, occurs in the prokaryote archaeon Sulfolobus acidocaldarius. In this organism the Mre11 protein interacts with the Rad50 protein and appears to have an active role in the repair of DNA damages experimentally introduced by gamma radiation. Similarly, during meiosis in the eukaryotic protist Tetrahymena Mre11 is required for repair of DNA damages, in this case double-strand breaks, by a process that likely involves homologous recombination. These observations suggest that human MRE11A is descended from prokaryotic and protist ancestral Mre11 proteins that served a role in early processes for repairing DNA damage.

Meal, Ready-to-Eat

The Meal, Ready-to-Eat – commonly known as the MRE – is a self-contained, individual field ration in lightweight packaging bought by the United States military for its service members for use in combat or other field conditions where organized food facilities are not available. The MRE replaced the canned MCI, or Meal, Combat, Individual rations, in 1981, and is the intended successor to the lighter LRP ration developed by the United States Army for Special Forces and Ranger patrol units in Vietnam.

History

The first soldier ration established by a Congressional Resolution, during the Revolutionary War, consisted of enough food to feed a man for one day, mostly beef, peas, and rice. During the Civil War, the military moved toward canned goods. Later, self-contained kits were issued as a whole ration and contained canned meat, pork, bread, coffee, sugar and salt. During the First World War, canned meats were replaced with lightweight preserved meats (salted or dried) to save weight and allow more rations to be carried by soldiers carrying their supplies on foot. At the beginning of World War II, a number of new field rations were introduced, including the Mountain ration and the Jungle ration. However, cost-cutting measures by Quartermaster Command officials during the latter part of World War II and the Korean War again saw the predominance of heavy canned C rations issued to troops, regardless of operating environment or mission. The use of canned wet rations continued through the Vietnam War, with the improved MCI field ration.

MRE (disambiguation)

MRE is a "Meal, Ready-to-Eat".

MRE may also refer to:

Cold (Maxwell song)

"Cold" is a song written by American R&B/soul singer Maxwell and Hod David. The song is the B-side to his number-one R&B hit single "Pretty Wings", and released from his album BLACKsummers'night. Cold was released as a single in June 2009, peaking to number-one on Billboard's Hot R&B/Hip-Hop Singles Sales and number-two on Hot 100 Singles Sales.

Although "Cold" failed to chart on Billboard Hot 100, it reached #62 on Billboard's Hot R&B/Hip-Hop Songs chart in July.

References

External links

John Gary

John Gary (born John Gary Strader; November 29, 1932 – January 4, 1998) was an American singer, recording artist, television host, and performer on the musical stage.

Early life

From Watertown, New York, Gary started singing at the age of 5. He joined his older sister, Shirley Strader. At the age of 9, he won a 3-year scholarship to the prestigious Cathedral School of St John in Manhattan. He auditioned for the choir master, Norman Coke-Jeffcott. At the age of 10, Gary had won two (2) pins of distinction from the American Theatre Wing Merchant Seaman's Club for the Stage Door Canteen. Aged 12, he toured the southern states with Frank Pursley, a blind pianist for the Mason Conservatory.

Career

Gary sang in movies, on Broadway, had his own television show, and appeared at Carnegie Hall, with numerous symphonies. He appeared thirty times as a guest on The Tonight Show with Jack Paar, Steve Allen and Johnny Carson. He traveled across the US and Canada with approximately 40 concerts per year. For six years he gave community concerts in over 400 cities and towns. He was a stylized singer, who recorded 23 albums for RCA Victor Records.

Nicole Scherzinger

Nicole Scherzinger (/niˈkoʊl ˈʃɜːrzɪŋər/; born Nicole Prescovia Elikolani Valiente; June 29, 1978) is an American recording artist, actress and television personality. Born in Honolulu, Hawaii and raised in Louisville, Kentucky, she performed in various singing competitions and musicals before joining American rock band Days of the New as a backing vocalist and later becoming one of the members of the ill-fated girl group Eden's Crush in 2001. She rose to fame as the lead singer of the burlesque troupe turned-recording act, the Pussycat Dolls becoming one of the world's best-selling girl groups of all time. During their hiatus Scherzinger planned to embark on her solo career with Her Name is Nicole but was later shelved after four singles failed to impact the charts. Following the disbandment of the Pussycat Dolls, Scherzinger became a judge for two seasons of The Sing-Off and in 2010 won the tenth season of Dancing with the Stars.

In 2011 she released her debut studio album, Killer Love to moderate success. It featured the top-ten hits "Don't Hold Your Breath" and "Right There". Later that year she served as a judge during the first season of the American version of The X Factor before heading to the UK version for two years in 2012. Her second studio album, Big Fat Lie (2014) had a minor impact on the charts. Its release was preceded by three singles including, "Your Love". For starring in the 2014 West End revival of the musical Cats Scherzinger garnered a Laurence Olivier Award nomination for Best Actress in a Supporting Role in a Musical.