Chorismic acid

Chorismic acid, more commonly known as its anionic form chorismate, is an important biochemical intermediate in plants and microorganisms. It is a precursor for:

The aromatic amino acids phenylalanine, tryptophan, and tyrosine

Indole, indole derivatives and tryptophan

2,3-Dihydroxybenzoic acid (DHB) used for enterobactin biosynthesis

The plant hormone salicylic acid

Many alkaloids and other aromatic metabolites.

The folate precursor para-aminobenzoate (pABA)

The biosynthesis of Vitamin K and folate in plants and microorganisms.

The name chorismic acid derives from a classical Greek word, χωρίζω meaning "to separate", because the compound plays a role as a branch-point in aromatic amino acid biosynthesis.

Biosynthesis

Shikimate → shikimate-3-phosphate → 5-enolpyruvylshikimate-3-phosphate (5-O-(1-carboxyvinyl)-3-phosphoshikimate)

Chorismate synthase is an enzyme that catalyzes the final chemical reaction 5-O-(1-carboxyvinyl)-3-phosphoshikimate → chorismate + phosphate.

Metabolism

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Chorismic acid

Biosynthesis

Metabolism

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