Chordoma
Chordoma is a rare slow-growing neoplasm thought to arise from cellular remnants of the notochord. The evidence for this is the location of the tumors (along the neuraxis), the similar immunohistochemical staining patterns, and the demonstration that notochordal cells are preferentially left behind in the clivus and sacrococcygeal regions when the remainder of the notochord regresses during fetal life.
Presentation
Chordomas can arise from bone in the skull base and anywhere along the spine. The two most common locations are cranially at the clivus and in the sacrum at the bottom of the spine.
Genetics
A small number of families have been reported in which multiple relatives have been affected by chordoma. In four of these families duplication of the brachyury gene was found to be responsible for causing chordoma.
A possible association with tuberous sclerosis complex (TSC1 or TSC2) has been suggested.
Epidemiology
In the United States, the annual incidence of chordoma is approximately 1 in one million (300 new patients each year).
Podcasts:
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by Rolling Stones
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by Neil Diamond
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by The Rolling Stones
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by Sarah Brightman
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by Tom Petty
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by Tom Petty & The Heartbreakers
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by Bob Marley
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by Heart
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by Dir En Grey
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by Pretty Things
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by Dirty Dancing soundtrack
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by Solomon Burke
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by O-Zone
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by Loleatta Holloway
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by Ronnie Mcdowell
CRY TO ME
by: Rolling StonesWhen your baby leaves you all alone
And nobody call you on the phone
Doncha feel like crying
Doncha feel like crying like crying like crying
C'mon baby, cry to me
When you're all alone in your lonely room
And there's nothing but the smell of her perfume
Doncha feel like crying
Doncha feel like crying like crying like crying
C'mon baby, (c'mon) cry to me
Nothing could be sadder than a glass of wine alone
Loneliness loneliness, it just a waste of your time
But you don't ever you don't ever have to walk alone
You see, so c'mon take my hand
C'mon walk with me
When you're waiting for a voice to come
In the night there is no one
Doncha feel like crying
Doncha feel like crying like crying like crying
C'mon baby, cry to me
C'mon baby, that's right cry to me
Yes, I want you to come on baby
C'mon c'mon cry to me
I want you to c'mon baby
C'mon c'mon and cry to me
Yeah c'mon baby c'mon I want you to cry cry cry to me
Yeah I want you to cry cry cry cry cry cry cry