Cholestasis

Cholestasis is a condition where bile cannot flow from the liver to the duodenum. The two basic distinctions are an obstructive type of cholestasis where there is a mechanical blockage in the duct system that can occur from a gallstone or malignancy, and metabolic types of cholestasis which are disturbances in bile formation that can occur because of genetic defects or acquired as a side effect of many medications.

Signs and symptoms

itchiness (pruritus). Pruritus is the primary symptom of cholestasis and is thought to be due to interactions of serum bile acids with opioidergic nerves. In fact, the opioid antagonist naltrexone is used to treat pruritus due to cholestasis.

jaundice. Jaundice is an uncommon occurrence in intrahepatic cholestasis, but is common in obstructive cholestasis.

pale stool. This symptom implies obstructive cholestasis.

dark urine

Causes

Possible causes:

Pregnancy

Androgens

Birth Control pills

Antibiotics (such as, TMP/SMX)

abdominal mass (e.g. cancer)

biliary atresia and other pediatric liver diseases

This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Cholestasis

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Cholestasis

Signs and symptoms

Causes

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