CHMP5

Charged multivesicular body protein 5 is a protein that in humans is encoded by the CHMP5 gene.

Function

CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.

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Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

CHMP6

Charged multivesicular body protein 6 is a protein that in humans is encoded by the CHMP6 gene.

References

Further reading

VPS24

Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.

Function

This gene encodes a protein that acts in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants encoding different isoforms.

Interactions

VPS24 has been shown to interact with IGFBP7.

References

Further reading