DNA replication factor Cdt1 is a protein that in humans is encoded by the CDT1 gene.
The protein encoded by this gene is a key licensing factor which, along with the protein Cdc6, functions to license DNA by forming the pre-replication complex (pre-RC). Its activity during the cell cycle is tightly regulated by its association with the protein geminin, which both inhibits Cdt1 activity during S phase in order to prevent re-replication of DNA and prevents it from ubiquitination and subsequent proteolysis.
CDT1 belongs to a family of replication proteins conserved from yeast to humans. Examples of orthlogs in other species include:
DNA replication factor CDT1 has been shown to interact with SKP2. Cdt1 is recruited by the origin recognition complex in origin licensing. Null-mutations for Cdt1 are lethal in yeast; the spores undergo mitosis without DNA replication. The overexpression of Cdt1 causes rereplication in H. sapiens, which activates the Chk1 pathway, preventing entry into mitosis.
Pathetic lies spewing from their hearts
A plague of weakness kept alive for too long
It's consuming and killing the people
Searching for cure in a god of the waste
Praying to idols so old and rotten
I, the snake, let me offer alternatives
Celebrate, the majestic self – Antichristianity
This is my unreligion – Antichristianity
Hereby I present a new age
An era of darkness to swallow the false
Blessed be thee who speaks with tongues of fire
Trample the cross and Crumble the corpse
blaspheme the old, let nothing stop you
Open the gates to self preservation
Unfold in liberty
Death to god, death to Jesus
Put an end to their miserable world
Death to god, death to Jesus
We are as mighty as gods
Death to god, death to Jesus
Put an end to their miserable world
Death to god, death to Jesus