CDC5L

Cell division cycle 5-like protein is a protein that in humans is encoded by the CDC5L gene.

Function

The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.

Interactions

CDC5L has been shown to interact with:

  • ASF/SF2,
  • BZW1,
  • CWC15,
  • DNA-PKcs,
  • DYNC1H1,
  • GCN1L1,
  • HSPA8,
  • ILF2,
  • PLRG1,
  • PPM1D,
  • PPP1CA,
  • PRPF19,
  • RBMX and
  • RPL12,
  • RPL13,
  • RPS16,
  • RPS25,
  • SF3A1,
  • SF3B1,
  • SF3B2,
  • SF3B4,
  • SFPQ,
  • SFRS2,
  • SNRPA1,
  • SNRPD3,
  • SRRM1,
  • Small nuclear ribonucleoprotein D1,
  • Small nuclear ribonucleoprotein D2,
  • Small nuclear ribonucleoprotein polypeptide A,
  • TOP2A, and
  • TTF2.
  • References

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