| CD84 molecule | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CD84; LY9B; SLAMF5; hCD84; mCD84 | ||||||||||||
| External IDs | OMIM: 604513 MGI: 1336885 HomoloGene: 48249 GeneCards: CD84 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8832 | 12523 | |||||||||||
| Ensembl | ENSG00000066294 | ENSMUSG00000038147 | |||||||||||
| UniProt | Q9UIB8 | Q18PI6 | |||||||||||
| RefSeq (mRNA) | NM_001184879.1 | NM_001252472.1 | |||||||||||
| RefSeq (protein) | NP_001171808.1 | NP_001239401.1 | |||||||||||
| Location (UCSC) | Chr 1: 160.51 – 160.55 Mb |
Chr 1: 173.77 – 173.82 Mb |
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| PubMed search | [1] | [2] | |||||||||||
CD84 (Cluster of Differentiation 84) is a human protein encoded by the CD84 gene.[1]
Members of the CD2 (see MIM 186990) subgroup of the Ig superfamily, such as CD84, have similar patterns of conserved disulfide bonds and function in adhesion interactions between T lymphocytes and accessory cells.[supplied by OMIM][1]
Contents |
Interactions [link]
CD84 has been shown to interact with SH2D1A.[2][3][4][5]
See also [link]
References [link]
- ^ a b "Entrez Gene: CD84 CD84 molecule". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8832.
- ^ Tangye, Stuart G; Nichols Kim E, Hare Nathan J, van de Weerdt Barbara C M (Sep. 2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation". J. Immunol. (United States) 171 (5): 2485–95. ISSN 0022-1767. PMID 12928397.
- ^ Sayós, J; Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun. 2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood (United States) 97 (12): 3867–74. DOI:10.1182/blood.V97.12.3867. ISSN 0006-4971. PMID 11389028.
- ^ Tangye, Stuart G; van de Weerdt Barbara C M, Avery Danielle T, Hodgkin Philip D (Jun. 2002). "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2". Eur. J. Immunol. (Germany) 32 (6): 1640–9. DOI:10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S. ISSN 0014-2980. PMID 12115647.
- ^ Morra, M; Simarro-Grande M, Martin M, Chen A S, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck M J, Sumegi J, Engel P, Li S C, Terhorst C (Sep. 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". J. Biol. Chem. (United States) 276 (39): 36809–16. DOI:10.1074/jbc.M101305200. ISSN 0021-9258. PMID 11477068.
Further reading [link]
- Andreesen R, Bross KJ, Osterholz J, Emmrich F (1986). "Human macrophage maturation and heterogeneity: analysis with a newly generated set of monoclonal antibodies to differentiation antigens". Blood 67 (5): 1257–64. PMID 3008886.
- Kingsmore SF, Souryal CA, Watson ML, et al. (1995). "Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1". Immunogenetics 42 (1): 59–62. DOI:10.1007/BF00164988. PMID 7797269.
- de la Fuente MA, Pizcueta P, Nadal M, et al. (1997). "CD84 leukocyte antigen is a new member of the Ig superfamily". Blood 90 (6): 2398–405. PMID 9310491.
- Krause SW, Rehli M, Heinz S, et al. (2000). "Characterization of MAX.3 antigen, a glycoprotein expressed on mature macrophages, dendritic cells and blood platelets: identity with CD84". Biochem. J. 346 Pt 3 (3): 729–36. DOI:10.1042/0264-6021:3460729. PMC 1220906. PMID 10698700. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220906.
- Palou E, Pirotto F, Solé J, et al. (2000). "Genomic characterization of CD84 reveals the existence of five isoforms differing in their cytoplasmic domains". Tissue Antigens 55 (2): 118–27. DOI:10.1034/j.1399-0039.2000.550203.x. PMID 10746783.
- Lucas AD, Chadwick N, Warren BF, et al. (2001). "The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo". Am. J. Pathol. 158 (3): 855–66. DOI:10.1016/S0002-9440(10)64034-5. PMC 1850344. PMID 11238035. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1850344.
- Shlapatska LM, Mikhalap SV, Berdova AG, et al. (2001). "CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A". J. Immunol. 166 (9): 5480–7. PMID 11313386.
- Sayós J, Martín M, Chen A, et al. (2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood 97 (12): 3867–74. DOI:10.1182/blood.V97.12.3867. PMID 11389028.
- Lewis J, Eiben LJ, Nelson DL, et al. (2001). "Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family". Clin. Immunol. 100 (1): 15–23. DOI:10.1006/clim.2001.5035. PMID 11414741.
- Morra M, Simarro-Grande M, Martin M, et al. (2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". J. Biol. Chem. 276 (39): 36809–16. DOI:10.1074/jbc.M101305200. PMID 11477068.
- Martin M, Romero X, de la Fuente MA, et al. (2001). "CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1". J. Immunol. 167 (7): 3668–76. PMID 11564780.
- Morra M, Lu J, Poy F, et al. (2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J. 20 (21): 5840–52. DOI:10.1093/emboj/20.21.5840. PMC 125701. PMID 11689425. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125701.
- Tangye SG, van de Weerdt BC, Avery DT, Hodgkin PD (2002). "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2". Eur. J. Immunol. 32 (6): 1640–9. DOI:10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S. PMID 12115647.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Del Valle JM, Engel P, Martín M (2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2)". J. Biol. Chem. 278 (19): 17430–7. DOI:10.1074/jbc.M301569200. PMID 12621057.
- Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation". J. Immunol. 171 (5): 2485–95. PMID 12928397.
- Zaiss M, Hirtreiter C, Rehli M, et al. (2003). "CD84 expression on human hematopoietic progenitor cells". Exp. Hematol. 31 (9): 798–805. DOI:10.1016/S0301-472X(03)00187-5. PMID 12962726.
- Romero X, Benítez D, March S, et al. (2005). "Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4)". Tissue Antigens 64 (2): 132–44. DOI:10.1111/j.1399-0039.2004.00247.x. PMID 15245368.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Nanda N, Andre P, Bao M, et al. (2005). "Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling". Blood 106 (9): 3028–34. DOI:10.1182/blood-2005-01-0333. PMID 16037392.
External links [link]
- CD84+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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