Interleukin-2 receptor subunit beta is a protein that in humans is encoded by the IL2RB gene.[1]
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.[1]
IL2RB has been shown to interact with HGS,[2] Janus kinase 1,[3][4][5][6][7] CISH[8] and SHC1.[9][10]
- ^ a b "Entrez Gene: IL2RB interleukin 2 receptor, beta". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3560.
- ^ Yamashita, Yuki; Kojima Katsuhiko, Tsukahara Tomonori, Agawa Hideyuki, Yamada Koichiro, Amano Yuji, Kurotori Naoki, Tanaka Nobuyuki, Sugamura Kazuo, Takeshita Toshikazu (May. 2008). "Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain". J. Cell. Sci. (England) 121 (Pt 10): 1727–38. DOI:10.1242/jcs.024455. ISSN 0021-9533. PMID 18445679.
- ^ Miyazaki, T; Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu Z J, Oishi I, Silvennoinen O, Witthuhn B A, Ihle J N (November 1994). "Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits". Science (UNITED STATES) 266 (5187): 1045–7. DOI:10.1126/science.7973659. ISSN 0036-8075. PMID 7973659.
- ^ Russell, S M; Johnston J A, Noguchi M, Kawamura M, Bacon C M, Friedmann M, Berg M, McVicar D W, Witthuhn B A, Silvennoinen O (November 1994). "Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID". Science (UNITED STATES) 266 (5187): 1042–5. DOI:10.1126/science.7973658. ISSN 0036-8075. PMID 7973658.
- ^ Usacheva, Anna; Kotenko Sergei, Witte Michael M, Colamonici Oscar R (August 2002). "Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors". J. Immunol. (United States) 169 (3): 1302–8. ISSN 0022-1767. PMID 12133952.
- ^ Zhu, M H; Berry J A, Russell S M, Leonard W J (April 1998). "Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta". J. Biol. Chem. (UNITED STATES) 273 (17): 10719–25. DOI:10.1074/jbc.273.17.10719. ISSN 0021-9258. PMID 9553136.
- ^ Migone, T S; Rodig S, Cacalano N A, Berg M, Schreiber R D, Leonard W J (November 1998). "Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation". Mol. Cell. Biol. (UNITED STATES) 18 (11): 6416–22. ISSN 0270-7306. PMC 109227. PMID 9774657. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=109227.
- ^ Aman, M J; Migone T S, Sasaki A, Ascherman D P, Zhu M h, Soldaini E, Imada K, Miyajima A, Yoshimura A, Leonard W J (October 1999). "CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling". J. Biol. Chem. (UNITED STATES) 274 (42): 30266–72. DOI:10.1074/jbc.274.42.30266. ISSN 0021-9258. PMID 10514520.
- ^ Delespine-Carmagnat, M; Bouvier G, Bertoglio J (January 2000). "Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain". Eur. J. Immunol. (GERMANY) 30 (1): 59–68. DOI:10.1002/1521-4141(200001)30:1<59::AID-IMMU59>3.0.CO;2-1. ISSN 0014-2980. PMID 10602027.
- ^ Ravichandran, K S; Burakoff S J (January 1994). "The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation". J. Biol. Chem. (UNITED STATES) 269 (3): 1599–602. ISSN 0021-9258. PMID 8294403.
- Ellery JM, Nicholls PJ (2002). "Alternate signalling pathways from the interleukin-2 receptor.". Cytokine Growth Factor Rev. 13 (1): 27–40. DOI:10.1016/S1359-6101(01)00023-5. PMID 11750878.
- Purvis SF, Georges DL, Williams TM, Lederman MM (1992). "Suppression of interleukin-2 and interleukin-2 receptor expression in Jurkat cells stably expressing the human immunodeficiency virus Tat protein.". Cell. Immunol. 144 (1): 32–42. DOI:10.1016/0008-8749(92)90223-C. PMID 1394441.
- Torigoe T, Saragovi HU, Reed JC (1992). "Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line.". Proc. Natl. Acad. Sci. U.S.A. 89 (7): 2674–8. DOI:10.1073/pnas.89.7.2674. PMC 48724. PMID 1557373. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=48724.
- Maslinski W, Remillard B, Tsudo M, Strom TB (1992). "Interleukin-2 (IL-2) induces tyrosine kinase-dependent translocation of active raf-1 from the IL-2 receptor into the cytosol.". J. Biol. Chem. 267 (22): 15281–4. PMID 1639773.
- Miyazaki T, Maruyama M, Yamada G, et al. (1991). "The integrity of the conserved 'WS motif' common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction.". EMBO J. 10 (11): 3191–7. PMC 453042. PMID 1915291. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=453042.
- Shibuya H, Yoneyama M, Nakamura Y, et al. (1990). "The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignment.". Nucleic Acids Res. 18 (13): 3697–703. DOI:10.1093/nar/18.13.3697. PMC 331067. PMID 1973832. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=331067.
- Hatakeyama M, Kono T, Kobayashi N, et al. (1991). "Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association.". Science 252 (5012): 1523–8. DOI:10.1126/science.2047859. PMID 2047859.
- Mills GB, May C, McGill M, et al. (1990). "Interleukin 2-induced tyrosine phosphorylation. Interleukin 2 receptor beta is tyrosine phosphorylated.". J. Biol. Chem. 265 (6): 3561–7. PMID 2303462.
- Oyaizu N, Chirmule N, Kalyanaraman VS, et al. (1990). "Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA.". Proc. Natl. Acad. Sci. U.S.A. 87 (6): 2379–83. DOI:10.1073/pnas.87.6.2379. PMC 53690. PMID 2315327. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=53690.
- Gnarra JR, Otani H, Wang MG, et al. (1990). "Human interleukin 2 receptor beta-chain gene: chromosomal localization and identification of 5' regulatory sequences.". Proc. Natl. Acad. Sci. U.S.A. 87 (9): 3440–4. DOI:10.1073/pnas.87.9.3440. PMC 53916. PMID 2333293. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=53916.
- Tsudo M, Kitamura F, Miyasaka M (1989). "Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies.". Proc. Natl. Acad. Sci. U.S.A. 86 (6): 1982–6. DOI:10.1073/pnas.86.6.1982. PMC 286829. PMID 2467293. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=286829.
- Hatakeyama M, Tsudo M, Minamoto S, et al. (1989). "Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's.". Science 244 (4904): 551–6. DOI:10.1126/science.2785715. PMID 2785715.
- Kornfeld H, Cruikshank WW, Pyle SW, et al. (1988). "Lymphocyte activation by HIV-1 envelope glycoprotein.". Nature 335 (6189): 445–8. DOI:10.1038/335445a0. PMID 2843775.
- Leonard WJ, Donlon TA, Lebo RV, Greene WC (1985). "Localization of the gene encoding the human interleukin-2 receptor on chromosome 10.". Science 228 (4707): 1547–9. DOI:10.1126/science.3925551. PMID 3925551.
- Bamborough P, Hedgecock CJ, Richards WG (1995). "The interleukin-2 and interleukin-4 receptors studied by molecular modelling.". Structure 2 (9): 839–51. DOI:10.1016/S0969-2126(94)00085-9. PMID 7529123.
- Minami Y, Nakagawa Y, Kawahara A, et al. (1995). "Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway.". Immunity 2 (1): 89–100. DOI:10.1016/1074-7613(95)90081-0. PMID 7600304.
- Giri JG, Kumaki S, Ahdieh M, et al. (1995). "Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.". EMBO J. 14 (15): 3654–63. PMC 394440. PMID 7641685. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=394440.
- Kirken RA, Rui H, Evans GA, Farrar WL (1993). "Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit.". J. Biol. Chem. 268 (30): 22765–70. PMID 7693677.
- Puri RK, Leland P, Aggarwal BB (1995). "Constitutive expression of human immunodeficiency virus type 1 tat gene inhibits interleukin 2 and interleukin 2 receptor expression in a human CD4+ T lymphoid (H9) cell line.". AIDS Res. Hum. Retroviruses 11 (1): 31–40. DOI:10.1089/aid.1995.11.31. PMID 7734194.
- Miyazaki T, Liu ZJ, Kawahara A, et al. (1995). "Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation.". Cell 81 (2): 223–31. DOI:10.1016/0092-8674(95)90332-1. PMID 7736574.
|
PDB gallery
|
|
|
|
|
2b5i: cytokine receptor complex
|
|
|
|
2erj: Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2
|
|
|
|
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
|
|
|
Chemokine receptor
(GPCRs) |
|
|
| TNF receptor |
|
|
| JAK-STAT |
|
|
| Ig superfamily |
|
|
| IL-17 family |
|
|
| S/T |
|
|
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
|
|
