The calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ion. In the parathyroid gland, the calcium-sensing receptor controls calcium homeostasis by regulating the release of parathyroid hormone (PTH).
The release of PTH is inhibited in response to elevations in plasma calcium concentrations and activation of the calcium receptor. Increased calcium binding on the extracellular side gives a conformational change in the receptor, which, on the intracellular side, initiates the phospholipase C pathway, presumably through a Gqα type of G protein, which ultimately increases intracellular concentration of calcium, which inhibits vesicle fusion and exocytosis of parathyroid hormone. It also inhibits (not stimulates, as some sources state) the cAMP dependent pathway.
Mutations that inactivate a CaSR gene cause familial hypocalciuric hypercalcemia (FHH) (also known as familial benign hypercalcemia because it is generally asymptomatic and does not require treatment), when present in heterozygotes. Patients who are homozygous for CaSR inactivating mutations have more severe hypercalcemia. Other mutations that activate CaSR are the cause of autosomal dominant hypocalcemia or Type 5 Bartter syndrome. An alternatively spliced transcript variant encoding 1088 aa has been found for this gene, but its full-length nature has not been defined.
CASR may stand for:
puddem up puddem up
hip hoppin’ up to the mic not hoppin’ on the rude boy tip I’m makin’
suckers kinda tipsy ‘cause I’m
constantly lippy lippy people tend to shut up cause I’m shuttin’ ‘em down down is where you’ll be
headed if you’re stepping’ in my direction direction provided steel town is where I’m residin’ residin’
in my mind is all the thoughts of leavin’ you blind blind to what surrounds when my lyrics reach your
ear drum drum and base is all I need to wipe out so called champions
now I rock rhymes that make a lot of sense don’t talk nonsense at all when I’m shootin’ this ill type
scripture so everybody gets the picture that my shits boom bap so everybody step back
ohhh-a-aaaah hip hop and rock and rock and roll are causin’ total devastation
ohhh-a-aaaah people tried it before it never sat quite right
ohhh-a-aaaah lovin’ the hip rock a new style of conversation
ohhh-a-aaaah bein' true to myself and now it sits quite nice
critics want to tell me that I’m causin’ too many crossovers with the genres that I’m choosin’
abusin’ the system of creativity but rules are meant to be broken as you are witnessing here comes
the drunken mountie able and willing I’m shooting lyrics that kill getting everybody high put you
fists in the sky no longer will I have to struggle with the lame idea that music is becomin too
predictable susceptible to media hype and all the hype that surrounds you when I’m rocking the mic
when I’m rocking the mic ya
ohhh-a-aaaah hip hop and rock and rock and roll are causin’ total devastation
ohhh-a-aaaah people tried it before it never sat quite right
ohhh-a-aaaah lovin’ the hip rock a new style of conversation
ohhh-a-aaaah bein' true to myself and now it sits quite nice
puddem up puddem up
so it seems you want to fight fight for what is right or so it seems or so it seems seems like it’s the time
time to set it off off with your head head to head I’m challengin’ emcees mentally successfully successfully
I’m climbin’ up the ladder and you’re looking behind you but it’s too late I just zipped by you,
with out the use of force force my way into your mind mind over matter matter resolve resolve it quick and diligent
diligent and efficiently efficiently smoking emcees yes I’m smoking emcees
now I rock rhymes that make a lot of sense don’t talk nonsense all when I’m shootin this il type
scripture so everybody gets the picture that my shits boom bap so everybody step back
ohhh-a-aaaah hip hop and rock and rock and roll are causin’ total devastation
ohhh-a-aaaah people tried it before it never sat quite right
ohhh-a-aaaah lovin’ the hip rock a new style of conversation
ohhh-a-aaaah bein' true to myself and now it sits quite nice
puddem up puddem up
hip hop and rock and rock and roll are causin’ total devastation
hip hop and rock and rock and roll are causin’ total devastation
hip hop and rock and rock and roll are causin’ total devastation