Aromatase
Aromatase, also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens. It is a member of the cytochrome P450 superfamily (EC 1.14.14.1), which are monooxygenases that catalyze many reactions involved in steroidogenesis. In particular, aromatase is responsible for the aromatization of androgens into estrogens. The aromatase enzyme can be found in many tissues including gonads, brain, adipose tissue, placenta, blood vessels, skin, and bone, as well as in tissue of endometriosis, uterine fibroids, breast cancer, and endometrial cancer. It is an important factor in sexual development.
Function
Aromatase is localized in the endoplasmic reticulum where it is regulated by tissue-specific promoters that are in turn controlled by hormones, cytokines, and other factors. It catalyzes the last steps of estrogen biosynthesis from androgens (specifically, it transforms androstenedione to estrone and testosterone to estradiol). These steps include three successive hydroxylations of the 19-methyl group of androgens, followed by simultaneous elimination of the methyl group as formate and aromatization of the A-ring.
CYP17A1
Cytochrome P450 17A1, or steroid 17-alpha-monooxygenase, or 17α-hydroxylase/17,20 lyase/17,20 desmolase is an enzyme that in humans is encoded by the CYP17A1 gene. It is found in the zona reticularis of the adrenal cortex and zona fasciculata as well as gonadal tissues. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are generally regarded as monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids, including the remarkable carbon-carbon bond scission catalyzed by this enzyme. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities, and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens.
More specifically, CYP17A1 acts upon pregnenolone and progesterone to add a hydroxyl (-OH) group at carbon 17 of the steroid D ring (the hydroxylase activity), or acts upon 17-hydroxyprogesterone and 17-hydroxypregnenolone to split the side-chain off the steroid nucleus (the lyase activity).
Cholest-4-en-3-one 26-monooxygenase
Cholest-4-en-3-one 26-monooxygenase (EC 1.14.13.141, CYP125, CYP125A1, cholest-4-en-3-one 27-monooxygenase) is an enzyme with system name cholest-4-en-3-one,NADH:oxygen oxidoreductase (26-hydroxylating). This enzyme catalyses the following chemical reaction
Cholest-4-en-3-one 26-monooxygenase is a heme thiolate (P450) enzyme.
References
External links
Podcasts:
CYP
ALBUMS
- In Dust And Rail Part. 2 EP released: 2010
- The Saw US EP released: 2010
- Vétérante Habileté released: 2007
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by Subb
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by S.O.A.P.
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by Saybia
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by Saybia
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by Zuba
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'Diskathing
by: SubbYou may not care but don't be naive
Well take The best The positive aspect
Have some friends and a punkska band
I guess that's The key to your sobriety
Even if you're a pervert use your head
Before you date this girl, you better sure you've bled
It's o.k. you'll do some mistakes
Like Ace Ventura with Snowflakes
Ohhhhhhhhhhhhhh!
Life is like diskathing
And someday you'll have a lovely wife
You'll do like O.J. and kill her with a knife
You'll obey to your bastard dog
Live across The street from a big fat slob
You will be a fucking statistic
Another man without a diploma
But after all you'll be happy
Cause you know man, this is The key
[Chorus]
[Bridge]
[Solo]
Ba-ba-ba, ba-Barbara ann!!! [x3]
[Chorus]
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