Prostaglandin DP2 receptor
Prostaglandin D2 receptor 2 (DP2) is a human protein encoded by the PTGDR2 gene. DP2 has also been designated as CD294 (cluster of differentiation 294).
Function
G protein-coupled receptors (GPCRs), such as DP2, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM]
DP2 has recently been found when activated by elevated level of prostaglandin D2 (PGD2), it could inhibit hair growth. This suggests the DP2 pathway as a potential target for bald treatment. A particularly promising compound for blocking the DP2 pathway is a compound known as TM30089, which exhibits a "functional insurmountability" of PGD2 expression.
Ligands
Agonists
Antagonists
Podcasts:
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by Hunter Hayes
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by Tyler Burkum
Cry With You
by: Hunter HayesWhen you try not to look at me
Scared that I'll see you hurting
You're not hiding anything,no
And frankly its got me worried
Nobody knows you better than I do
I keep my promises, I'm fighting for you
You're not alone
I'll listen 'till your tears give out
You're safe and sound, I swear that I won't let you down
What's hurting you I, I feel it too
I mean it when I say
When you cry, I cry with you, with you
I'm not going any place
I just hate to see you like this
No, I can't make it go away
Oh, but keeping it inside won't fix it
I can't give you every answer that you need
But I wanna hear everything you wanna tell me
You're not alone
I'll listen 'till your tears give out
You're safe and sound, I swear that I won't let you down
What's hurting you I, I feel it too
I mean it when I say
When you cry, I cry with you, oh
Yeah, I cry with you
You need love tough enough to count on
So here I am
You're not alone
I'll listen 'till your tears give out
You're safe and sound, I swear that I won't let you down
What's hurting you I, I feel it too
I mean it when I say
When you cry, I cry
I mean it when I say
When you cry, I cry with you, oh