CRTC1

CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (Transducer Of Regulated CREB activity 1, not to be confused with the unrelated target of rapamycin complex 1 (mTORC1)) is a protein that in humans is encoded by the CRTC1 gene. It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands.

Clinical significance

Production of CRTC1 is blocked in Alzheimer's disease.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.