Cyclic AMP-responsive element-binding protein 3 is a protein that in humans is encoded by the CREB3 gene.
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.
CREB3 has been shown to interact with Host cell factor C1.
The Human Genome Organisation (HUGO) is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world. The HUGO Gene Nomenclature Committee (HGNC), sometimes referred to as "HUGO", is one of HUGO's most active committees and aims to assign a unique gene name and symbol to each human gene.
HUGO was established in late April 1988 at the first meeting dedicated to genome mapping at Cold Spring Harbor. The idea of starting the organization stemmed from a South African biologist by the name of Sydney Brenner, who is known for his significant contributions to work on the genetic code and other areas of molecular biology, as well as winning the Nobel prize in Physiology of Medicine in 2002. A Founding Council was elected at the meeting that total 42 scientists from 17 different countries. HUGO is grounded in Geneva Switzerland, and later went on to elect an additional 178 members, bringing the total up to 220.
What's happenin'?
What you're cryin' for?
You know you look too damn good to be cryin'
Come here
Do do do do do yeah yeah)
How about a player
DPG style
You know
You know
When I think of our untimely end
And everything we could have been
I cry, baby I cry
So it's 5 AM and
I still can't sleep
Took some medicine
But it's not working
Someone's clinging to me
And it's bittersweet
'Cause he's head over heels
But it ain't that deep
I finally changed my number
Got a different pager
Then last saturday
Your cousin called to say you're
Tryin' to reach me
Probably because you see that
I'm with someone new
Late at night like a little child
Wandering 'round alone
In my new friend's home
On my tippy toes
So that he won't know
(So that he won't know)
I still cry baby
(I cry baby)
Over you and me
Sipping Bailey's Cream
By the stereo
Trying to find relief
On the radio
I'm suppressing the tears
But they start to flow
'Cause the next song I hear
Is a song I wrote
When we first got together
Early that september
I can't bear to listen
So I might as well drift
In the kitchen
Pour another glass or two
And I try to forget you
(You)
Late at night like a little child
Wandering 'round alone
In my new friend's home
(In my new friend's home on my)
On my tippy toes
So that he won't know
(So that he won't know I)
I still cry baby
Over you and me
(You and me)
Baby hear me when I say
Let that man be on his way
Don't even waste your time
And worry how he handle thangz
(That ain't right) baby hear me when I say
A playa feelin' good today (u know ur 2 fly 2 be cryin')
Don't even waste your time watch how I handle (watch) thangz
Man ur a fool for this
For this)
But on the real dog I'm cool with this we do and this
D-O-DOUBLE G-Y
Kiss the girls and make them cry!
(It's late)
Late at night like a little child
(I'm like a little child)
Wandering around alone
(Wandering around alone)
In my new friend's home
(Do do do do do)
On my tippy toes
(Tippy toes)
So that he won't know
(So that he won't know)
I still cry baby
(I was babbling)
Over you and me
(Over you and me)
Why is it 5 AM and
I'm still struggeling and
Walking 'round no
Do do do do do do do
(On my tippy toes)
On my tippy toes
So that he won't know
I still cry baby
(I still cry)
Over you and me
I don't get no sleep
I'm half awake
Can't stop thinking of you and me
And everything we used to be
It could have been so perfectly
I cry
I cry
I cry
I gotta give me some sleep
Baby and I
On my tippy toes
So that he won't know
I still cry
You and I
Over you and me
Late at night like a little child
(Oh like a little child)
Wandering 'round alone
In my new friend's home
(Do do do do do)
(In my new friend's home)
On my tippy toes
So that he won't know
(So that he won't know)
I still cry
(Do do do do do)
(Do do do do do)
(Do do do do do)
(Do do do do do)
(Do do do do do)
Late at night like a little child
Wandering around alone
In my new friend's home
On my tippy toes
So that he won't know
I still cry baby
Over you and me
Do do do do do
Do do do do do
Do do do do do
Do do do do do
Cry baby
On my tippy toes
So that he won't know
I still cry
Mmmh