COQ7
The clk-1 (clock-1) gene encodes an enzyme (demethoxyubiquinone monooxygenase) that is necessary for ubiquinone biosynthesis in the worm Caenorhabditis elegans and other eukaryotes. The mouse version of the gene is called mclk-1 and the human, fruit fly and yeast homolog COQ7 (coenzyme Q biosynthesis protein 7).
CLK-1 is not to be confused with the unrelated human protein CLK1 which plays a role in RNA splicing.
Structure
The protein has two repeats of approximately 90 amino acids, that contain two conserved motifs predicted to be important for coordination of iron. The structure and function of the gene are highly conserved among different species.
The C. elegans protein contains 187 amino acid residues (20 kilodaltons), the human homolog 217 amino acid residues (24 kilodaltons, gene consisting of six exons spanning 11 kb and located on chromosome 16).
Mitochondrial function
Ubiquinone is a small redox active lipid that is found in most cellular membranes where it acts as a cofactor in numerous cellular redox processes, including mitochondrial electron transport. As a cofactor, ubiquinone is often involved in processes that produce reactive oxygen species (ROS). In addition, ubiquinone is one of the main endogenous antioxidants of the cell. The CLK-1 enzyme is responsible for the hydroxylation of 5-demethoxyubiquinone to 5-hydroxyubiquinone.
Podcasts:
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by K-7
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All That I Want
by: C21ALL THAT I WANT / C21
I just need you to know
That everytime you walk into a room I get a feeling
And I try to make it show
But every now and then it seems as though you don't believe it
Girl just dance
I like the way you move it
Just shake, shake, shake into the music
C'mon and dance
Don't worry about it
Don't need to play no games 'cause I love you just the same
(You turn) me on and on turn me on
The definition of all that I want
But you don't seem to hear me at all
I'm telling you
Baby you're all that I want
All that I want
All that I know
is your the only one that makes me feel the way you do girl
And time will show
That all this jealousy is just a waste of emotion
Girl just dance
I like the way you move it
Just shake, shake, shake into the music
C'mon and dance
Don't worry about it
Don't need to play no games 'cause I love you just the same
(You turn) me on and on turn me on
The definition of all that I want
But you don't seem to hear me at all
I'm telling you
Baby you're all that I want
All that I want
Just hear me now
I want you to know
I'm into you
And you alone
Just hear me now
I want you to know
I'm into you
And you alone
Girl just dance
I like the way you move it
Just shake, shake, shake into the music
C'mon and dance
Don't worry about it
Don't need to play no games 'cause I love you just the same
(You turn) me on and on turn me on
The definition of all that I want
But you don't seem to hear me at all
I'm telling you
Baby you're all that I want
(You) turn me on and on turn me on
The definition of all that I want
But you don't seem to hear me at all
I'm telling you
Baby you're all that I want
You're turning me on girl
C'mon and just dance girl
You're making me sweat girl