Langille Lake Water Aerodrome
Langille Lake Water Aerodrome (TC LID: CLL2) is located adjacent to Mahone Bay, Nova Scotia, Canada and is open from April to December.
References
Cll1
Toxin Cll1 is a toxin from the venom of the Mexican scorpion Centruroides limpidus limpidus, which changes the activation threshold of sodium channels by binding to neurotoxin binding site 4, resulting in increased excitability.
Etymology and Source
The toxin Cll1 is named after its producing species, Centruroides limpidus limpidus. Along with Cll1, multiple toxins are excreted in its venom.
Chemistry
Cll1 is a long chain neuropeptide belonging to the scorpion toxin superfamily. Cll1 is classified as a member of the beta-toxin subfamily. The global secondary structure of Cll1 is similar to that of other scorpion beta-toxins, including the alpha-helix, triple stranded antiparallel beta-sheet, and the four disulfide bridges. The higher affinity for crustacean rather than mammalian sodium channels has been attributed to the presence of Trp18, a hydrophobic amino acid at the surface of Cll1.
Target
Cll1 targets, like the classical scorpion beta-toxin, the voltage-gated sodium channels (Nav). Beta-toxins bind to the extracellular end of the voltage sensor S4 at the loop between the 3th and 4th segment of the second domain. By binding it alters the voltage dependent opening of the channel.
CLL
CLL is an abbreviation that can stand for:
