| Chloride channel, voltage-sensitive 6 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CLCN6; CLC-6 | ||||||||||||
| External IDs | OMIM: 602726 MGI: 1347049 HomoloGene: 985 IUPHAR: ClC-6 GeneCards: CLCN6 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 1185 | 26372 | |||||||||||
| Ensembl | ENSG00000011021 | ENSMUSG00000029016 | |||||||||||
| UniProt | P51797 | O35454 | |||||||||||
| RefSeq (mRNA) | NM_001256959.1 | NM_011929.2 | |||||||||||
| RefSeq (protein) | NP_001243888.1 | NP_036059.1 | |||||||||||
| Location (UCSC) | Chr 1: 11.87 – 11.9 Mb |
Chr 4: 147.38 – 147.41 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Chloride transport protein 6 is a protein that in humans is encoded by the CLCN6 gene.[1][2]
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 6 and 7 belong to a subbranch of this family. Chloride channel 6 has four different alternatively spliced transcript variants. This gene is in close vicinity to two other kidney-specific chloride channel genes, CLCNKA and CLCNKB.[2]
Contents |
See also [link]
References [link]
- ^ Brandt S, Jentsch TJ (Feb 1996). "ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family". FEBS Lett 377 (1): 15–20. DOI:10.1016/0014-5793(95)01298-2. PMID 8543009.
- ^ a b "Entrez Gene: CLCN6 chloride channel 6". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1185.
Further reading [link]
- Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. DOI:10.1093/dnares/9.3.99. PMID 12168954.
- Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223–9. DOI:10.1093/dnares/1.5.223. PMID 7584044.
- Eggermont J, Buyse G, Voets T, et al. (1997). "Alternative splicing of ClC-6 (a member of the CIC chloride-channel family) transcripts generates three truncated isoforms one of which, ClC-6c, is kidney-specific". Biochem. J. 325 ( Pt 1) (Pt 1): 269–76. PMC 1218554. PMID 9224655. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1218554.
- Eggermont J (1998). "The exon-intron architecture of human chloride channel genes is not conserved". Biochim. Biophys. Acta 1397 (2): 156–60. PMID 9565675.
- Lamb FS, Clayton GH, Liu BX, et al. (1999). "Expression of CLCN voltage-gated chloride channel genes in human blood vessels". J. Mol. Cell. Cardiol. 31 (3): 657–66. DOI:10.1006/jmcc.1998.0901. PMID 10198195.
- Kornak U, Bösl MR, Kubisch C (1999). "Complete genomic structure of the CLCN6 and CLCN7 putative chloride channel genes(1)". Biochim. Biophys. Acta 1447 (1): 100–6. PMID 10500249.
- Lamb FS, Graeff RW, Clayton GH, et al. (2001). "Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium". Am. J. Respir. Cell Mol. Biol. 24 (4): 376–81. PMID 11306429.
- Tran P, Leclerc D, Chan M, et al. (2003). "Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms". Mamm. Genome 13 (9): 483–92. DOI:10.1007/s00335-002-2167-6. PMID 12370778.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. DOI:10.1101/gr.4039406. PMC 1356129. PMID 16344560. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. DOI:10.1038/nature04727. PMID 16710414.
External links [link]
- CLCN6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it. |
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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