CLCN1
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen).
Chloride channel protein, skeletal muscle (CLCN1) is a protein that in humans is encoded by the CLCN1 gene. Mutations in this protein cause congenital myotonia.
CLCN1 is critical for the normal function of skeletal muscle cells. For the body to move normally, skeletal muscles must tense (contract) and relax in a coordinated way. Muscle contraction and relaxation are controlled by the flow of ions into and out of muscle cells. CLCN1 forms an ion channel that controls the flow of negatively charged chloride ions into these cells. The main function of this channel is to stabilize the cells' electrical charge, enabling muscles to contract normally.
Podcasts:
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by Colcannon
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by Colcannon
Send The Boats Away
by: ColcannonOnce on sea on sea of silver fishermen will cast there
nets,
To take the bounty from the sea those men are fishing
yet,
But now there boats are laden down with goods of evil
score,
And in these peace times we should fear those sea bound
men of war.
Send the boats away my friend, Send the boats away,
We care not how we run them out, Send the boats away,
And if we choose to live in peace who are they to say,
Take a stand protect this land, Send the boats away.
Who will want these nuclear holds, when the nets are
raised,
And death comes to our ocean when the seas are full of
waste,
Our fishing boat, or fishing boats lie useless on the
shore,
And bearing down upon them now, those sea bound men of
war.
Send the boats away my friend, Send the boats away,
We care not how we run them out, Send the boats away,
And if we choose to live in peace who are they to say,
Take a stand protect this land, Send the boats away.
Once I lay easy in my bed, mind free from hollow cause,
Now it seams our nuclear brine pacific sons we’ve lost,
For now those boats are laden down with goods of lethal
store,
And in these peace times we should fear those sea bound
men of war.
Send the boats away my friend, Send the boats away,
We care not how we run them out, Send the boats away,
And if we choose to live in peace who are they to say,
Take a stand protect this land, Send the boats away.