CIT (gene)

Citron Rho-interacting kinase is an enzyme that in humans is encoded by the CIT gene.

Structure

Citron is a 183 kDa protein that contains a C6H2 zinc finger, a PH domain, and a long coiled-coil forming region including 4 leucine zippers and a rho/rac binding site. It is was discovered as a rho/rac effector in 1995, interacting only with the GTP bound forms of rho and rac 1. Displaying a distinctive protein organization, this protein defines a separate class of rho partners. Using a cloning approach based on the polymerase chain reaction (PCR), a splice variant of citron, citron kinase (citron-K) has been identified with an alternative amino terminus. This N-terminal extension contains a protein kinase domain that has approximately 50% sequence identity to the sequences of ROCK, ROK, myotonic dystrophy protein kinase (MDPK) and the Cdc42 effector known as MRCK or GEK. Citron kinase, which resembles the ROCK family of kinases and by comparison to it, is therefore a multiple domain protein containing an N-terminal kinase domain, an internal coiled-coil (CC) domain with Rho/Rac interacting site, and a C-terminal region consisting of a Zn finger, a pleckstrin homology (PH) domain, a Citron homology domain (CNH), a putative SH3 binding domain, and a PDZ-targeting motif. Its fly (Drosophila) ortholog is called Sticky. the importance of different domains of citron-K in its localization at different stages is discussed below.

Eugene (given name)

Eugene is a common (masculine) first name that comes from the Greek εὐγενής (eugenēs), "noble", literally "well-born", from εὖ (eu), "well" and γένος (genos), "race, stock, kin".Gene is a common shortened form. The feminine variant is Eugenia or Eugénie.

Male foreign-language variants include:

Notable people

Christianity

Military

Gene (novel)

Gene is a thriller novel by Stel Pavlou (born 1970), published in 2005 in England by Simon & Schuster. It is published in several languages with some title changes. The Italian edition has the title La Conspirazione del Minotauro (The Minotaur Conspiracy). The novel is about a fictional New York detective, James North, who in the process of hunting down a criminal, uncovers a genetics experiment to unlock past lives through genetic memory, therefore achieving a kind of immortality. In so doing North discovers his own origins, that of a soldier from the Trojan War who is reincarnated seven times through history, forced to confront his nemesis each time, all for the loss of his one true love.

Characters

Cyclades (born circa 1300 BC)

Incarnations of Cyclades

Athanatos (born circa 1500 BC)

Incarnations of Athanatos

Gene (disambiguation)

A gene is a chemical structure effecting biological inheritance.

Gene also may refer to:

Given names:

Printed works:

Fictional characters:

Other:

See also

Cité

Cité may refer to:

See also

CIT

CIT may refer to:

Educational institutions

Other organizations

Biology and medicine

Cit (consciousness)

Chit (चित्) is a Sanskrit word meaning awareness or consciousness, "true awareness", "to be aware of", "to understand", "to comprehend". It is a core principle in all ancient spiritual traditions originating from the Indian subcontinent. In Upanishads it is referred to as the Drishta or the Seer, the Sense that makes sense of all other sense experiences. Chit is one of the three aspects forming the Satcitananda nature of the Absolute, according to the Vedic scriptures.

The term is widely used and discussed among Hinduism, Sikhism, Jainism and other religious systems.

Chitaranjan is who gives you the feeling of awareness and total consciousness.

See also

References

Further reading

External links