Chuk

Chuk may refer to:

Chuk (instrument)

The chuk (hangul: 축; hanja: 柷) is a traditional Korean musical instrument used in Confucian (Munmyo) and Royal Ancestral Shrine (Jongmyo) ceremonies to signal the beginning of a ritual music performance. It consists of a square wooden box, played by striking the bottom with a mallet to mark beats or sections. The chuk is derived from the Chinese zhu, and was imported from China during the Goryeo Dynasty.

References

See also

CHUK

Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. However, IKK-α has many additional cellular targets, and is thought to function independently of the NF-κB pathway to regulate epidermal differentiation.

Function

NF-κB response

IKK-α is a member of the serine/threonine protein kinase family and forms a complex in the cell with IKK-β and NEMO. NF-κB transcription factors are normally held in an inactive state by the inhibitory proteins IκBs. IKK-α and IKK-β phosphorylate the IκB proteins, marking them for degradation via ubiquitination and allowing NF-κB transcription factors to go into the nucleus.

Once activated, NF-κB transcription factors regulate genes that are implicated in many important cellular processes, including immune response, inflammation, cell death, and cell proliferation.