Charged multivesicular body protein 5 is a protein that in humans is encoded by the CHMP5 gene.
CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.
This gene encodes a protein that acts in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants encoding different isoforms.
VPS24 has been shown to interact with IGFBP7.
Here in the dark
I stand before you
Knowing this is my chance to show you my heart
This is the start
This is the start
I have so much to say and I'm hopin'
That your arms are open
Don't turn away, I want you near me
But you have to hear me
Here's where I stand
Here's who I am
Love me, but don't tell me who I have to be
Here's who I am, I'm what you see
You said I had to change and I was tryin'
But my heart was lyin'
I'm not that child any longer
I am stronger
Here's where I stand
Here's who I am
Help me to move on but please don't tell me how
I'm on my way, I'm movin' now
In this life we've come so far
But we're only who we are
With the courage of love
To show us the way
We've got the power to stand up and say
Here's where I stand
Here's where I am
Stand up and be counted, I'm counting on you
If you're with me
We'll make it through
Here's where I stand
Here's who I am
Love me, love me, love me and we'll make it through
Here's where I stand
Baby, baby, baby I'm counting on you
Here's where I stand
Love me, love me, love me and we'll make it through
I'm counting
I'm counting