CHM

CHM may refer to:

Museums

Medicine and biology

Other uses

Master of Surgery

The Master of Surgery (Latin: Magister Chirurgiae) is an advanced qualification in surgery. Depending upon the degree, it may be abbreviated Ch.M., M.Ch., M.Chir. or M.S. At a typical medical school the program lasts between two and three years. The possession of a medical degree is a prerequisite. The Ch.M. can be awarded on both clinical and academic competency or on academic competency. The regulations may ask for surgical experience and a thesis topic that is not purely medical, but otherwise there is little to distinguish the ChM from the MD.

History

The Masters of Surgery, or Ch.M. is an advanced qualification in surgical medicine, established in Great Britain in the middle of the 19th Century. The qualification was designed to be awarded as a higher degree to the Bachelor of Surgery degree (usually Ch.B.).

Many universities have stopped holding written and clinical examinations for the Ch.M., and focused solely on the thesis and oral examination. Only Oxford and Cambridge still have a ("Part One") examination before submission of the thesis and oral examination on the same for the degrees which they abbreviate as M.Ch. and M.Chir. respectively.

Rab escort protein

Rab escort protein 1 also known as rab proteins geranylgeranyltransferase component A 1 is an enzyme that in humans is encoded by the CHM gene.

Function

This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane.

Interactions

CHM (gene) has been shown to interact with RAB1A,RAB7A and RAB3A.

Clinical significance

Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina.

See also

References

Further reading

External links