CHEK2

CHEK2 is the official symbol for the human gene Checkpoint kinase 2. CHEK2 is located on the long (q) arm of chromosome 22. CHEK2 is tumor suppressor gene that encodes the protein CHK2, a serine threonine kinase. CHK2 operates in an intricate network of proteins to elicit DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linked to a wide range of cancers including breast cancer.

Other names for CHK2 include CDS1, Cds1 kinase, checkpoint-like protein CHK2, CHK2, CHK2 checkpoint homolog, CHK2_HUMAN, Chk2 protein kinase, hCds1 protein, hCHK2, HuCds1, RAD53, serine/threonine-protein kinase CHK2.

Gene location

The CHEK2 gene is located on the long (q) arm of chromosome 22 at position 12.1. In other words, its location of chromosome 22 stretches from base pair 28,687,742 to base pair 28,741,904.

Protein structure

The CHK2 protein encoded by the CHEK2 gene is a serine threonine kinase. The protein consists of 543 amino acids and the following domains: