Cenpi

Centromere protein I

Identifiers

CENPI; CENP-I; FSHPRH1; LRPR1; Mis6

External IDs

OMIM: 300065 MGI: 2147897 HomoloGene: 4899 GeneCards: CENPI Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• kinetochore • nucleus • nucleoplasm • chromosome • cytosol
Biological process	• M phase of mitotic cell cycle • mitotic prometaphase • mitotic cell cycle • nucleosome assembly • sex differentiation • CenH3-containing nucleosome assembly at centromere • follicle-stimulating hormone signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
100.35 – 100.42 Mb

Chr X:
130.84 – 130.9 Mb

PubMed search

[1]

[2]

Centromere protein I is a protein that in humans is encoded by the CENPI gene.^[1]^[2]

The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis.^[2]

References [link]

^ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol 8 (5): 446–57. DOI:10.1038/ncb1396. PMID 16622420.
^ ^a ^b "Entrez Gene: CENPI centromere protein I". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2491.

Further reading [link]

Izuta H, Ikeno M, Suzuki N, et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells.". Genes Cells 11 (6): 673–84. DOI:10.1111/j.1365-2443.2006.00969.x. PMID 16716197.
Foltz DR, Jansen LE, Black BE, et al. (2006). "The human CENP-A centromeric nucleosome-associated complex.". Nat. Cell Biol. 8 (5): 458–69. DOI:10.1038/ncb1397. PMID 16622419.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. DOI:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1459365.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. DOI:10.1038/nature03440. PMC 2665286. PMID 15772651. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2665286.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.". Genes Cells 9 (2): 105–20. DOI:10.1111/j.1365-2443.2004.00705.x. PMID 15009096.
Liu ST, Hittle JC, Jablonski SA, et al. (2003). "Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis.". Nat. Cell Biol. 5 (4): 341–5. DOI:10.1038/ncb953. PMID 12640463.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Roberts RG, Kendall E, Vetrie D, Bobrow M (1997). "Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene.". Genomics 37 (1): 122–4. DOI:10.1006/geno.1996.0528. PMID 8921378.
Slegtenhorst-Eegdeman KE, Post M, Baarends WM, et al. (1995). "Regulation of gene expression in Sertoli cells by follicle-stimulating hormone (FSH): cloning and characterization of LRPR1, a primary response gene encoding a leucine-rich protein.". Mol. Cell. Endocrinol. 108 (1-2): 115–24. DOI:10.1016/0303-7207(94)03468-9. PMID 7758824.
Adams MD, Dubnick M, Kerlavage AR, et al. (1992). "Sequence identification of 2,375 human brain genes.". Nature 355 (6361): 632–4. DOI:10.1038/355632a0. PMID 1538749.

This article on a gene on the X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

Genetics: chromosomes

General

Karyotype · Ploidy · Meiosis

Classification

Autosome · Sex chromosome · Microchromosome

Evolution

Chromosomal inversion · Chromosomal translocation · Polyploidy · Paleopolyploidy

Structure

Nucleosome

Telomere: Telomere-binding protein (TINF2)

Chromatid

Chromatin	Euchromatin · Heterochromatin

Histone	H1 · H2A · H2B · H3 · H4

Centromere	A · B · C1 · C2 · E · F · H · I · J · K · M · N · O · P · Q · T

B strc: edmb (perx), skel (ctrs), epit, cili, mito, nucl (chro)

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References [link]

Further reading [link]

https://wn.com/CENPI

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