CENPA
Centromere protein A, also known as CENPA, is a protein which in humans is encoded by the CENPA gene.
Function
Centromeres are the chromosomal domains that specify the mitotic behavior of chromosomes. The CENPA gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
In higher eukaryotes, the recruitment of CENP-A nucleosomes to existing centromeres is an epigenetic process, independent of the underlying DNA sequence. In S.pombe, de novo recruitment of the CENP-A to the centromere is believed to be controlled by "centromeric" heterochromatin surrounding the centromere, and by an RNAi mechanism. The RNAi is cut to form siRNA; this complexes with the protein Chp1, which then binds the centromeric heterochromatin. This helps recruit other proteins, ultimately resulting in a protein complex that forms cohesin between two sister chromatids at the centromeric heterochromatin. This cohesin is believed to be essential in replacing the centromere H3 with CENP-A. CENP-A is one of the epigenetic changes that is believed to distinguish centromeric DNA from other DNA. Once the CENP-A has been added, the centromere becomes self-propagating, and the surrounding heterochromatin/RNAi mechanism is no longer necessary.
Human Genome Organisation
The Human Genome Organisation (HUGO) is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world. The HUGO Gene Nomenclature Committee (HGNC), sometimes referred to as "HUGO", is one of HUGO's most active committees and aims to assign a unique gene name and symbol to each human gene.
History
HUGO was established in late April 1988 at the first meeting dedicated to genome mapping at Cold Spring Harbor. The idea of starting the organization stemmed from a South African biologist by the name of Sydney Brenner, who is known for his significant contributions to work on the genetic code and other areas of molecular biology, as well as winning the Nobel prize in Physiology of Medicine in 2002. A Founding Council was elected at the meeting that total 42 scientists from 17 different countries. HUGO is grounded in Geneva Switzerland, and later went on to elect an additional 178 members, bringing the total up to 220.
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The Power
by: Snap![Foreign content]
I've got the power, hey, yeah, hey
Like the crack of the whip, I snap attack
Front to back in this thing called rap
Dig it like a shovel, rhyme Devil on a Heavenly level
Bang the bass, turn up the treble
Radical mind day and night all the time
Seven, fourteen, wise, divine
Maniac, brainiac, winning the game
I'm the lyrical Jesse James
Oh, yeah, yeah
Oh yeah, gettin' kinda heavy
It's getting', it's getting', it's gettin' kinda heavy
It's getting', it's getting', it's gettin' kinda heavy
It's getting', it's getting', it's gettin' kinda heavy
It's getting', it's getting', it's gettin' kinda heavy
(I've got the power)
He's gonna break my heart
He's gonna break my heart of hearts
He's gonna break my heart
He's gonna break my heart of hearts
(I've got the power, oh, oh, oh)
(I've got the power)
He's gonna break my heart
He's gonna break my heart of hearts
He's gonna break my heart
He's gonna break my heart of hearts
(I've got the power, oh, oh, oh)
It's getting', it's getting', it's gettin' kinda hectic
It's getting', it's getting', it's gettin' kinda hectic
It's getting', it's getting', it's gettin' kinda hectic
It's getting', it's getting', it's gettin' kinda hectic
Quality, I possess something, I'm fresh
When my voice goes through the rest
Of the microphone that I am holdin'
Copy written lyrics so they can't be stolen
If they are snap
Don't need the police to try to save them
Your voice will sink, so please, stay off my back
Or I will attack and you don't want that
(I've got the power)
He's gonna break my heart
He's gonna break my heart of hearts
He's gonna break my heart
He's gonna break my heart of hearts
(I've got the power, oh, oh, oh)
(I've got the power)
He's gonna break my heart
He's gonna break my heart of hearts
He's gonna break my heart
He's gonna break my heart of hearts
(I've got the power, oh, oh, oh)
Quality, I possess something, I'm fresh
When my voice goes through the rest
Of the microphone that I am holdin'
Copy written lyrics so they can't be stolen
If they are snap
Don't need the police to try to save them
Your voice will sink, so please, stay off my back
Or I will attack and you don't want that
(I've got the power)
He's gonna break my heart
He's gonna break my heart of hearts
He's gonna break my heart
He's gonna break my heart of hearts
(I've got the power, oh, oh, oh)
I've got the power, I've got the power
I've got the power, I've got the power
I've got the power, I've got the power
(Power)
It's getting', it's getting', it's gettin' kinda hectic
It's getting', it's getting', it's gettin' kinda hectic
It's getting', it's getting', it's gettin' kinda hectic
It's getting', it's getting', it's gettin' kinda hectic
It's getting', it's getting', it's gettin' kinda hectic
It's getting', it's getting', it's gettin' kinda hectic
It's getting', it's getting', it's gettin' kinda hectic
It's getting', it's getting', it's gettin' kinda hectic
(Power)
I've got the power, I've got the power
I've got the power, I've got the power
Power
I've got the power, power
I've got the power, power, I've got, I've got