| Cadherin 16, KSP-cadherin | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | CDH16[] | ||||||||||||
| External IDs | OMIM: 603118 MGI: 106671 HomoloGene: 2997 GeneCards: CDH16 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 1014 | 12556 | |||||||||||
| Ensembl | ENSG00000166589 | ENSMUSG00000031881 | |||||||||||
| UniProt | O75309 | O88338 | |||||||||||
| RefSeq (mRNA) | NM_001204744.1 | NM_001252627.1 | |||||||||||
| RefSeq (protein) | NP_001191673.1 | NP_001239556.1 | |||||||||||
| Location (UCSC) | Chr 16: 66.94 – 66.95 Mb |
Chr 8: 107.13 – 107.15 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Cadherin-16 is a protein that in humans is encoded by the CDH16 gene.[1][2][3]
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development.[3]
References [link]
- ^ Thomson RB, Ward DC, Quaggin SE, Igarashi P, Muckler ZE, Aronson PS (Oct 1998). "cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin". Genomics 51 (3): 445–51. DOI:10.1006/geno.1998.5402. PMID 9721215.
- ^ Thomson RB, Igarashi P, Biemesderfer D, Kim R, Abu-Alfa A, Soleimani M, Aronson PS (Aug 1995). "Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific member of the cadherin multigene family". J Biol Chem 270 (29): 17594–601. DOI:10.1074/jbc.270.29.17594. PMID 7615566.
- ^ a b "Entrez Gene: CDH16 cadherin 16, KSP-cadherin". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1014.
Further reading [link]
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Thomson RB, Aronson PS (1999). "Immunolocalization of Ksp-cadherin in the adult and developing rabbit kidney.". Am. J. Physiol. 277 (1 Pt 2): F146–56. PMID 10409308.
- Baudry D, Jeanpierre C (2000). "Assignment of E-cadherin (CDH1) and KSP-cadherin (CDH16) to chromosome 16q22.1 by radiation hybrid mapping.". Cytogenet. Cell Genet. 88 (3-4): 253–4. DOI:10.1159/000015531. PMID 10828602.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Thomson RB, Mentone S, Kim R, et al. (2003). "Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD.". Am. J. Physiol. Renal Physiol. 285 (5): F870–80. DOI:10.1152/ajprenal.00153.2003. PMID 12851251.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. DOI:10.1101/gr.1293003. PMC 403697. PMID 12975309. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
- Wendeler MW, Praus M, Jung R, et al. (2004). "Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin.". Exp. Cell Res. 294 (2): 345–55. DOI:10.1016/j.yexcr.2003.11.022. PMID 15023525.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Hishikawa K, Marumo T, Miura S, et al. (2005). "Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16.". Biochem. Biophys. Res. Commun. 328 (1): 288–91. DOI:10.1016/j.bbrc.2004.12.167. PMID 15670782.
- Thedieck C, Kuczyk M, Klingel K, et al. (2005). "Expression of Ksp-cadherin during kidney development and in renal cell carcinoma.". Br. J. Cancer 92 (11): 2010–7. DOI:10.1038/sj.bjc.6602597. PMC 2361784. PMID 15886705. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2361784.
- Kuehn A, Paner GP, Skinnider BF, et al. (2007). "Expression analysis of kidney-specific cadherin in a wide spectrum of traditional and newly recognized renal epithelial neoplasms: diagnostic and histogenetic implications.". Am. J. Surg. Pathol. 31 (10): 1528–33. DOI:10.1097/PAS.0b013e318058818c. PMID 17895753.
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https://wn.com/CDH16
Human Genome Organisation
The Human Genome Organisation (HUGO) is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world. The HUGO Gene Nomenclature Committee (HGNC), sometimes referred to as "HUGO", is one of HUGO's most active committees and aims to assign a unique gene name and symbol to each human gene.
History
HUGO was established in late April 1988 at the first meeting dedicated to genome mapping at Cold Spring Harbor. The idea of starting the organization stemmed from a South African biologist by the name of Sydney Brenner, who is known for his significant contributions to work on the genetic code and other areas of molecular biology, as well as winning the Nobel prize in Physiology of Medicine in 2002. A Founding Council was elected at the meeting that total 42 scientists from 17 different countries. HUGO is grounded in Geneva Switzerland, and later went on to elect an additional 178 members, bringing the total up to 220.
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Sleepwalking
by: KittieWatching me fall
Into the flames
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[Chorus]
Sleep as day dies
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Wander aimlessly through the night
Love and regret
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Please let me sleep
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[Chorus]
And I walk with these ghosts
And I walk with these ghosts
And I walk with these ghosts...
[Chorus]
Sleep as night falls
Sleepwalk with the dead
Hope keeps me alive