CD99
CD99 antigen (Cluster of differentiation 99), also known as MIC2 or single-chain type-1 glycoprotein, is a heavily O-glycosylated transmembrane protein that is encoded by the CD99 gene in humans. The protein has a mass of 32 kD. Unusually for a gene present on the X chromosome, the CD99 gene does not undergo X inactivation, and it was the first such pseudoautosomal gene to be discovered in humans.
Expression
It is expressed on all leukocytes but highest on thymocytes and is believed to augment T-cell adhesion and apoptosis of double positive t cells.It has been found in endothelial cells and in the periodontium, including gingival fibroblasts and gingival epithelial cells. It also participates in migration and activation. There is also experimental evidence that it binds to cyclophilin A.
It is found on the cell surface of Ewing's sarcoma tumors and is positive in granulosa cell tumors. It is more expressed in malignant gliomas than in the brain, and such overexpression results in higher levels of invasiveness and lower rates of survival. Antibodies to CD99 are used in diagnostic immunohistochemistry to distinguish Ewing's sarcoma from other tumours of similar histological appearance, as well as for the identification of thymic tumours, and of spindle cell tumours, such as synovial sarcoma, haemangiopericytoma, and meningioma. EWS/FLI is thought to regulate CD99, but knockdown of EWS/FLI results in only a modest reduction in CD99. When CD99 expression is knocked down in human cells with Ewing’s sarcoma and those cells are grafted onto mice, tumor and bone metastasis development is reduced.
Podcasts:
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Kidd Video
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by Kidd Video
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by Kidd Video
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by Kidd Video
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by Kidd Kidd
YOU GOT ME
by: Keith Sweat[Lox]
Uh, yeah, uh huh, yeah
Yeah, yeah, yeah, uh huh, yeah, yeah
It's another one
Uh huh, yeah, yeah
It's another one, and another one
You got me where you want me
You could listen to Levert while leaving the country
And then sweat it out when you feel comfy
Or play Gill to the minute that ou say you're hungry
Uh, you got me where you want me
You could listen to Levert while leaving the country
And then sweat it out when you're feeling comfy
Or play gill to the minute that you say you're hungry
Uh, you got me where you want me
You could listen to Levert while leaving the country
And then Sweat it out when your'e feeling comfy
Or play Gill to the minute that you say you're hungry
[LSG]
I know
You need
Love and understanding
Sometimes
Feel like
I can't give you more of my time
You keep on wanting me
To be there girl
But I can't be
Why you keep stressing me
When you know I'm doing my best
I keep on telling you
I do the best that I can do
How can I get through to you
Everything I do is for you
1 - You got me where you want me
Tell me what you need
Take me baby
Tell me what you want
Anywhere you wanna go is for me
You got me where you want me
I can't keep on going through these changes
The more you doubt me
You keep pusing me away girl
You keep on wanting more
I'm doing my best
I'm doing everything for you
Repeat 1
Girl, you got me yearning
Yearning to know what I'll do with love
Can you tell me what I'm doing
But I'm always saying you don't understand
I'll never leave you alone
Repeat 1
Repeat Lox