CD97
Cluster of differentiation 97 is a protein also known as BL-Ac[F2] encoded by the ADGRE5 gene. CD97 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
CD97 is widely expressed on, among others, hematopoietic stem and progenitor cells, immune cells, epithelial cells, muscle cells as well as their malignant counterparts. In the case of CD97 the N-terminal domains consist of alternatively spliced epidermal growth factor (EGF)-like domains. Alternative splicing has been observed for this gene and three variants have been found. The N-terminal fragment of CD97 contains 3-5 EGF-like domains in human and 3-4 EGF-like domains in mice.
Ligands
Decay accelerating factor (DAF/CD55), a regulatory protein of the complement cascade, interacts with the first and second EGF-like domains of CD97; chondroitin sulfate B with the fourth EGF-like domain; α5β1 and αvβ3 integrins with an RGD downstream the EGF-like domains; and CD90 (Thy-1) with the GAIN domain. N-glycosylation of CD97 within the EGF domains is crucial for CD55 binding.
Podcasts:
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Kidd Video
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by Kidd Video
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by Kidd Video
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by Kidd Video
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by Kidd Kidd
YOU GOT ME
by: Keith Sweat[Lox]
Uh, yeah, uh huh, yeah
Yeah, yeah, yeah, uh huh, yeah, yeah
It's another one
Uh huh, yeah, yeah
It's another one, and another one
You got me where you want me
You could listen to Levert while leaving the country
And then sweat it out when you feel comfy
Or play Gill to the minute that ou say you're hungry
Uh, you got me where you want me
You could listen to Levert while leaving the country
And then sweat it out when you're feeling comfy
Or play gill to the minute that you say you're hungry
Uh, you got me where you want me
You could listen to Levert while leaving the country
And then Sweat it out when your'e feeling comfy
Or play Gill to the minute that you say you're hungry
[LSG]
I know
You need
Love and understanding
Sometimes
Feel like
I can't give you more of my time
You keep on wanting me
To be there girl
But I can't be
Why you keep stressing me
When you know I'm doing my best
I keep on telling you
I do the best that I can do
How can I get through to you
Everything I do is for you
1 - You got me where you want me
Tell me what you need
Take me baby
Tell me what you want
Anywhere you wanna go is for me
You got me where you want me
I can't keep on going through these changes
The more you doubt me
You keep pusing me away girl
You keep on wanting more
I'm doing my best
I'm doing everything for you
Repeat 1
Girl, you got me yearning
Yearning to know what I'll do with love
Can you tell me what I'm doing
But I'm always saying you don't understand
I'll never leave you alone
Repeat 1
Repeat Lox