CD86

Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells.

The CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily.Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.

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Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

CD86 (album)

CD86: 48 Tracks from the Birth of Indie Pop is a compilation album of artists from the original C86 era, released in 2006 by Sanctuary Records. It is compiled by Bob Stanley of Saint Etienne.

To coincide with its release, the Institute of Contemporary Arts hosted "C86 - Still Doing It For Fun", an exhibition and two nights of gigs celebrating the rise of British independent music.

Background

Released in 1986, the original compilation album C86 became very influential, and is today credited as the birth of indie pop. Stanley notes: "It was the beginning of indie music. It's hard to remember how underground guitar music and fanzines were in the mid-'80s. DIY ethics and any residual punk attitudes were in isolated pockets around the country, and the C86 comp and gigs brought them together". For the original's twentieth anniversary in 2006, Stanley compiled the set of songs that was released as CD86.

Description

CD86 is inspired by C86. Only three of the songs on C86 appear on CD86; fifteen of the original groups on C86 have alternative tracks on CD86. Several tracks were little-known before the album's release.