Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.
ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular matrix proteins.
The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').
CD49c has been shown to interact with:
This dog is no puppy dog
she's strange as the trees
she's brown as the mountain
and white as the breeze
she walks on the water
without any boots
her eyes arc as fine
as the music of flutes
but she will not sweep chimneys
nor will she pluck corn
but she is the best little dog
that ever was born
I have lain in the womb
of the rocks cold and chill
while she speaks in my heart
with the voice of the hill
and when I am risen
and ready to run
she will laugh without laughter
to welcome the sun
but she will not learn language
nor will she bear scorn
but she is the best little dog
that ever was born
The water god offered me
the ring of his rings
to buy the dog from me
to teach --->she<--- poor kings
the ring's on my finger
the dog runs behind
since watery palaces
would ne'er suit her mind
but as yet she can't fly well
nor play on the horn
still she is the best little dog
that ever was born.