CD47
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα).
CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a key role in immune and angiogenic responses. CD47 is ubiquitously expressed in human cells and has found to be overexpressed in many different tumor cells.
Structure
CD47 is a 50 kDa membrane receptor that has extracellular N-terminal IgV domain, five transmembrane domains, and a short C-terminal intracellular tail. There are four alternatively spliced isoforms of CD47 that differ only in the length of their cytoplasmic tail.
Form 2 is the most widely expressed form that is found in all circulating and immune cells. The second most abundant isoform is form 4, which is predominantly expressed in the brain and in the peripheral nervous system. Only keratinocytes expressed significant amounts of form 1. Little is known about the functional significance of this alternative splicing. However, these isoforms are highly conserved between mouse and man, suggesting an important role for the cytoplasmic domains in CD47 function.
Podcasts:
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Keith Sweat
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by Kidd Video
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by Kidd Video
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by Kidd Video
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by Kidd Video
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by Kidd Kidd
YOU GOT ME
by: Keith Sweat[Lox]
Uh, yeah, uh huh, yeah
Yeah, yeah, yeah, uh huh, yeah, yeah
It's another one
Uh huh, yeah, yeah
It's another one, and another one
You got me where you want me
You could listen to Levert while leaving the country
And then sweat it out when you feel comfy
Or play Gill to the minute that ou say you're hungry
Uh, you got me where you want me
You could listen to Levert while leaving the country
And then sweat it out when you're feeling comfy
Or play gill to the minute that you say you're hungry
Uh, you got me where you want me
You could listen to Levert while leaving the country
And then Sweat it out when your'e feeling comfy
Or play Gill to the minute that you say you're hungry
[LSG]
I know
You need
Love and understanding
Sometimes
Feel like
I can't give you more of my time
You keep on wanting me
To be there girl
But I can't be
Why you keep stressing me
When you know I'm doing my best
I keep on telling you
I do the best that I can do
How can I get through to you
Everything I do is for you
1 - You got me where you want me
Tell me what you need
Take me baby
Tell me what you want
Anywhere you wanna go is for me
You got me where you want me
I can't keep on going through these changes
The more you doubt me
You keep pusing me away girl
You keep on wanting more
I'm doing my best
I'm doing everything for you
Repeat 1
Girl, you got me yearning
Yearning to know what I'll do with love
Can you tell me what I'm doing
But I'm always saying you don't understand
I'll never leave you alone
Repeat 1
Repeat Lox